Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103072285> ?p ?o ?g. }
- W2103072285 endingPage "1785" @default.
- W2103072285 startingPage "1781" @default.
- W2103072285 abstract "Since the initial discovery of mutations in the isocitrate dehydrogenase 1 (IDH1) gene in a large subset of human low-grade gliomas and acute myelogenous leukemia (AML), much interest focused on the function of IDH1 and on the relationship between mutations in IDH1 and tumor progression. To date, mutations in the IDH1 gene have been found in numerous cancers with the highest frequencies occurring in gliomas, chondrosarcomas/enchondromas and cholangiocarcinomas.IDH1 was first described in the scientific literature as early as 1950. Early researchers proposed that the enzyme likely functions in cellular lipid metabolism based on the observation that the enzymatic reaction produces NADPH and partially localizes to peroxisomes. This article highlights the studies implicating IDH1 in cytoplasmic and peroxisomal lipid metabolism from the early researchers to the recent studies examining mutant IDH1(R132), the most common IDH1 mutation found in cancer.While a role for IDH1 in lipid biosynthesis in the liver and adipose tissue is now established, a role in lipid metabolism in the brain and tumors is beginning to be examined. The recent discoveries that IDH1(R132H) interferes with the metabolism of phospholipids in gliomas and that IDH1 activity could participate in the synthesis of acetyl-CoA from glutamine in hypoxic tumors highlight roles for IDH1 in lipid metabolism in a broad spectrum of tissues.Interferences in cytoplasmic and peroxisomal lipid metabolism by IDH1(R132) may contribute to the more favorable clinical outcome in patients whose tumors express mutations in the IDH1 gene." @default.
- W2103072285 created "2016-06-24" @default.
- W2103072285 creator A5003826683 @default.
- W2103072285 date "2015-09-01" @default.
- W2103072285 modified "2023-09-27" @default.
- W2103072285 title "IDH1, lipid metabolism and cancer: Shedding new light on old ideas" @default.
- W2103072285 cites W10140315 @default.
- W2103072285 cites W1525523952 @default.
- W2103072285 cites W1542337165 @default.
- W2103072285 cites W1942172751 @default.
- W2103072285 cites W1964150693 @default.
- W2103072285 cites W1967190893 @default.
- W2103072285 cites W1981057948 @default.
- W2103072285 cites W1987049546 @default.
- W2103072285 cites W1988756388 @default.
- W2103072285 cites W1995490493 @default.
- W2103072285 cites W2005966972 @default.
- W2103072285 cites W2011376261 @default.
- W2103072285 cites W2012930481 @default.
- W2103072285 cites W2014602198 @default.
- W2103072285 cites W2018041848 @default.
- W2103072285 cites W2025104020 @default.
- W2103072285 cites W2031687154 @default.
- W2103072285 cites W2035409103 @default.
- W2103072285 cites W2040827479 @default.
- W2103072285 cites W2047867594 @default.
- W2103072285 cites W2049509016 @default.
- W2103072285 cites W2059708171 @default.
- W2103072285 cites W2073400782 @default.
- W2103072285 cites W2073972553 @default.
- W2103072285 cites W2080452140 @default.
- W2103072285 cites W2082158946 @default.
- W2103072285 cites W2096796171 @default.
- W2103072285 cites W2101986593 @default.
- W2103072285 cites W2110836663 @default.
- W2103072285 cites W2116516144 @default.
- W2103072285 cites W2119105243 @default.
- W2103072285 cites W2126817554 @default.
- W2103072285 cites W2128375620 @default.
- W2103072285 cites W2132555177 @default.
- W2103072285 cites W2134061682 @default.
- W2103072285 cites W2134831827 @default.
- W2103072285 cites W2137307574 @default.
- W2103072285 cites W2138708884 @default.
- W2103072285 cites W2152201022 @default.
- W2103072285 cites W2154313451 @default.
- W2103072285 cites W2163317400 @default.
- W2103072285 cites W2164816766 @default.
- W2103072285 cites W2201825351 @default.
- W2103072285 cites W2231081458 @default.
- W2103072285 cites W2324185971 @default.
- W2103072285 cites W4254846354 @default.
- W2103072285 cites W49726795 @default.
- W2103072285 cites W90835690 @default.
- W2103072285 doi "https://doi.org/10.1016/j.bbagen.2015.04.014" @default.
- W2103072285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25960387" @default.
- W2103072285 hasPublicationYear "2015" @default.
- W2103072285 type Work @default.
- W2103072285 sameAs 2103072285 @default.
- W2103072285 citedByCount "33" @default.
- W2103072285 countsByYear W21030722852016 @default.
- W2103072285 countsByYear W21030722852017 @default.
- W2103072285 countsByYear W21030722852018 @default.
- W2103072285 countsByYear W21030722852019 @default.
- W2103072285 countsByYear W21030722852020 @default.
- W2103072285 countsByYear W21030722852021 @default.
- W2103072285 countsByYear W21030722852022 @default.
- W2103072285 countsByYear W21030722852023 @default.
- W2103072285 crossrefType "journal-article" @default.
- W2103072285 hasAuthorship W2103072285A5003826683 @default.
- W2103072285 hasConcept C104317684 @default.
- W2103072285 hasConcept C121608353 @default.
- W2103072285 hasConcept C127078168 @default.
- W2103072285 hasConcept C127848430 @default.
- W2103072285 hasConcept C143065580 @default.
- W2103072285 hasConcept C181199279 @default.
- W2103072285 hasConcept C2777150147 @default.
- W2103072285 hasConcept C4733338 @default.
- W2103072285 hasConcept C502942594 @default.
- W2103072285 hasConcept C54355233 @default.
- W2103072285 hasConcept C55493867 @default.
- W2103072285 hasConcept C86803240 @default.
- W2103072285 hasConceptScore W2103072285C104317684 @default.
- W2103072285 hasConceptScore W2103072285C121608353 @default.
- W2103072285 hasConceptScore W2103072285C127078168 @default.
- W2103072285 hasConceptScore W2103072285C127848430 @default.
- W2103072285 hasConceptScore W2103072285C143065580 @default.
- W2103072285 hasConceptScore W2103072285C181199279 @default.
- W2103072285 hasConceptScore W2103072285C2777150147 @default.
- W2103072285 hasConceptScore W2103072285C4733338 @default.
- W2103072285 hasConceptScore W2103072285C502942594 @default.
- W2103072285 hasConceptScore W2103072285C54355233 @default.
- W2103072285 hasConceptScore W2103072285C55493867 @default.
- W2103072285 hasConceptScore W2103072285C86803240 @default.
- W2103072285 hasIssue "9" @default.
- W2103072285 hasLocation W21030722851 @default.
- W2103072285 hasLocation W21030722852 @default.
- W2103072285 hasOpenAccess W2103072285 @default.