FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103072608> ?p ?o ?g. }

• W2103072608 endingPage "5705" @default.
• W2103072608 startingPage "5697" @default.
• W2103072608 abstract "ABSTRACT Neisseria gonorrhoeae acetylates its cell wall peptidoglycan (PG) at the C-6 position on N -acetylmuramic acid. To understand the effects of PG acetylation on PG metabolism and release of PG fragments, we have made mutations in the genes responsible for PG acetylation. An insertion mutation in a putative PG acetylase gene (designated pacA ) resulted in loss of PG acetylation as detected by a high-performance liquid chromatography-based assay. Sequence analysis of a naturally occurring nonacetylating strain revealed the presence of a 26-bp deletion in pacA . Introduction of the deletion mutation into wild-type gonococci resulted in lack of acetylation, and the phenotype was complemented by the addition of a wild-type copy of pacA at a distant location on the chromosome. Mutations were also introduced into three genes downstream of pacA . The gene directly downstream of pacA was required for acetylation and was designated pacB , whereas the next two genes were not required. Sequences highly similar to pacA and pacB were also found in N. meningitidis and N. lactamica strains, and an insertion in the meningococcal pacA eliminated PG acetylation. Phenotypic analyses of an N. gonorrhoeae pacA mutant did not show any decrease in lysozyme resistance or serum resistance, and the release of PG fragments during growth was unchanged. However, purified PG from the wild-type strain was significantly more resistant to the action of human lysozyme than was PG purified from the pacA mutant. Interestingly, the pacA mutant was more sensitive to EDTA, a compound known to trigger autolysis." @default.
• W2103072608 created "2016-06-24" @default.
• W2103072608 creator A5053607368 @default.
• W2103072608 creator A5084479884 @default.
• W2103072608 date "2005-09-01" @default.
• W2103072608 modified "2023-09-26" @default.
• W2103072608 title "Mutations Affecting Peptidoglycan Acetylation in <i>Neisseria gonorrhoeae</i> and <i>Neisseria meningitidis</i>" @default.
• W2103072608 cites W1524005751 @default.
• W2103072608 cites W1538487830 @default.
• W2103072608 cites W1546761767 @default.
• W2103072608 cites W1556989342 @default.
• W2103072608 cites W1578918269 @default.
• W2103072608 cites W1594008356 @default.
• W2103072608 cites W1823966971 @default.
• W2103072608 cites W1908268229 @default.
• W2103072608 cites W1921782533 @default.
• W2103072608 cites W1922548901 @default.
• W2103072608 cites W1932645010 @default.
• W2103072608 cites W1949690724 @default.
• W2103072608 cites W1971388047 @default.
• W2103072608 cites W1975875000 @default.
• W2103072608 cites W1985381885 @default.
• W2103072608 cites W2028032368 @default.
• W2103072608 cites W2030829173 @default.
• W2103072608 cites W2040200245 @default.
• W2103072608 cites W2043136231 @default.
• W2103072608 cites W2063219607 @default.
• W2103072608 cites W2077482089 @default.
• W2103072608 cites W2077488719 @default.
• W2103072608 cites W2080274923 @default.
• W2103072608 cites W2083398339 @default.
• W2103072608 cites W2083596411 @default.
• W2103072608 cites W2095021212 @default.
• W2103072608 cites W2096775943 @default.
• W2103072608 cites W2100956503 @default.
• W2103072608 cites W2102153654 @default.
• W2103072608 cites W2118479026 @default.
• W2103072608 cites W2124664358 @default.
• W2103072608 cites W2125309974 @default.
• W2103072608 cites W2129267732 @default.
• W2103072608 cites W2131547551 @default.
• W2103072608 cites W2132878899 @default.
• W2103072608 cites W2150203465 @default.
• W2103072608 cites W2154986946 @default.
• W2103072608 cites W2170605332 @default.
• W2103072608 doi "https://doi.org/10.1128/iai.73.9.5697-5705.2005" @default.
• W2103072608 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1231103" @default.
• W2103072608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16113287" @default.
• W2103072608 hasPublicationYear "2005" @default.
• W2103072608 type Work @default.
• W2103072608 sameAs 2103072608 @default.
• W2103072608 citedByCount "60" @default.
• W2103072608 countsByYear W21030726082012 @default.
• W2103072608 countsByYear W21030726082013 @default.
• W2103072608 countsByYear W21030726082014 @default.
• W2103072608 countsByYear W21030726082015 @default.
• W2103072608 countsByYear W21030726082016 @default.
• W2103072608 countsByYear W21030726082017 @default.
• W2103072608 countsByYear W21030726082018 @default.
• W2103072608 countsByYear W21030726082019 @default.
• W2103072608 countsByYear W21030726082020 @default.
• W2103072608 countsByYear W21030726082021 @default.
• W2103072608 countsByYear W21030726082022 @default.
• W2103072608 countsByYear W21030726082023 @default.
• W2103072608 crossrefType "journal-article" @default.
• W2103072608 hasAuthorship W2103072608A5053607368 @default.
• W2103072608 hasAuthorship W2103072608A5084479884 @default.
• W2103072608 hasBestOaLocation W21030726081 @default.
• W2103072608 hasConcept C104317684 @default.
• W2103072608 hasConcept C119157956 @default.
• W2103072608 hasConcept C143065580 @default.
• W2103072608 hasConcept C153911025 @default.
• W2103072608 hasConcept C2776634448 @default.
• W2103072608 hasConcept C2776966407 @default.
• W2103072608 hasConcept C2778458888 @default.
• W2103072608 hasConcept C2779166590 @default.
• W2103072608 hasConcept C523546767 @default.
• W2103072608 hasConcept C54355233 @default.
• W2103072608 hasConcept C55493867 @default.
• W2103072608 hasConcept C86803240 @default.
• W2103072608 hasConcept C89423630 @default.
• W2103072608 hasConceptScore W2103072608C104317684 @default.
• W2103072608 hasConceptScore W2103072608C119157956 @default.
• W2103072608 hasConceptScore W2103072608C143065580 @default.
• W2103072608 hasConceptScore W2103072608C153911025 @default.
• W2103072608 hasConceptScore W2103072608C2776634448 @default.
• W2103072608 hasConceptScore W2103072608C2776966407 @default.
• W2103072608 hasConceptScore W2103072608C2778458888 @default.
• W2103072608 hasConceptScore W2103072608C2779166590 @default.
• W2103072608 hasConceptScore W2103072608C523546767 @default.
• W2103072608 hasConceptScore W2103072608C54355233 @default.
• W2103072608 hasConceptScore W2103072608C55493867 @default.
• W2103072608 hasConceptScore W2103072608C86803240 @default.
• W2103072608 hasConceptScore W2103072608C89423630 @default.
• W2103072608 hasIssue "9" @default.
• W2103072608 hasLocation W21030726081 @default.
• W2103072608 hasLocation W21030726082 @default.
• W2103072608 hasLocation W21030726083 @default.

• next