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- W2103072677 abstract "A two-dimensional microscopic transport model of the stratum corneum (SC) incorporating corneocytes of varying hydration and permeability embedded in an anisotropic lipid matrix is presented. Results are expressed in terms of a dimensionless permeability ( P ^ SC/w ) comp , which is a function of two dimensionless parameters, R and σ. R is a ratio of transbilayer to lateral molecular flows within a lipid bilayer and σ is the ratio of (lateral) permeability in the lipid phase, DlipKlip/w, to that in the corneocyte phase, DcorKcor/w. The shape of the dimensionless permeability surface is also governed by the arrangement of the SC lipids, where Model 1 represents the extreme in which lipid-phase transport can occur with no transbilayer transport, whereas Model 2 entails maximum transbilayer transport. Model calculations are exemplified by characterizing the skin permeability of four representative permeants: water, ethanol, nicotinamide, and testosterone. A comparison with experimental steady state permeability and partition data supports that the transport properties of the SC lipids are highly anisotropic, with lateral diffusivities several orders of magnitude higher than the equivalent diffusivity calculated from transbilayer hopping. Nevertheless, the calculations suggest that corneocyte-phase transport plays a major role for all four permeants. These results confirm our previous calculations on water permeability and present a marked contrast to the commonly stated doctrine that the SC transport pathway is primarily intercellular. © 2006 Wiley-Liss, Inc. and the American Pharmacists Association." @default.
- W2103072677 created "2016-06-24" @default.
- W2103072677 creator A5027934482 @default.
- W2103072677 creator A5037000812 @default.
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- W2103072677 date "2006-03-01" @default.
- W2103072677 modified "2023-10-04" @default.
- W2103072677 title "A Multiphase Microscopic Diffusion Model for Stratum Corneum permeability. I. Formulation, Solution, and Illustrative Results for Representative Compounds" @default.
- W2103072677 cites W120127816 @default.
- W2103072677 cites W1270055781 @default.
- W2103072677 cites W1524556707 @default.
- W2103072677 cites W1544311753 @default.
- W2103072677 cites W1561210178 @default.
- W2103072677 cites W1568499110 @default.
- W2103072677 cites W1594382975 @default.
- W2103072677 cites W1604173330 @default.
- W2103072677 cites W163549122 @default.
- W2103072677 cites W174346363 @default.
- W2103072677 cites W1930660744 @default.
- W2103072677 cites W1965977720 @default.
- W2103072677 cites W1968755046 @default.
- W2103072677 cites W1970865670 @default.
- W2103072677 cites W1972549014 @default.
- W2103072677 cites W1972859350 @default.
- W2103072677 cites W1976308074 @default.
- W2103072677 cites W1976772348 @default.
- W2103072677 cites W1976938630 @default.
- W2103072677 cites W1983355645 @default.
- W2103072677 cites W1984013252 @default.
- W2103072677 cites W1984319959 @default.
- W2103072677 cites W1992868334 @default.
- W2103072677 cites W1993379676 @default.
- W2103072677 cites W1995342205 @default.
- W2103072677 cites W1998682680 @default.
- W2103072677 cites W1999438233 @default.
- W2103072677 cites W2008084176 @default.
- W2103072677 cites W2008602846 @default.
- W2103072677 cites W2012933891 @default.
- W2103072677 cites W2013747389 @default.
- W2103072677 cites W2014720564 @default.
- W2103072677 cites W2015202908 @default.
- W2103072677 cites W2019020277 @default.
- W2103072677 cites W2020736683 @default.
- W2103072677 cites W2024452502 @default.
- W2103072677 cites W2026029590 @default.
- W2103072677 cites W2027105901 @default.
- W2103072677 cites W2036441926 @default.
- W2103072677 cites W2042461888 @default.
- W2103072677 cites W2042824450 @default.
- W2103072677 cites W2046868608 @default.
- W2103072677 cites W2048759973 @default.
- W2103072677 cites W2050329072 @default.
- W2103072677 cites W2053856970 @default.
- W2103072677 cites W2055368553 @default.
- W2103072677 cites W2055718543 @default.
- W2103072677 cites W2056440144 @default.
- W2103072677 cites W2058958777 @default.
- W2103072677 cites W2061566425 @default.
- W2103072677 cites W2061617831 @default.
- W2103072677 cites W2064007068 @default.
- W2103072677 cites W2064757248 @default.
- W2103072677 cites W2065608605 @default.
- W2103072677 cites W2068890467 @default.
- W2103072677 cites W2074792208 @default.
- W2103072677 cites W2082361370 @default.
- W2103072677 cites W2082986474 @default.
- W2103072677 cites W2085750563 @default.
- W2103072677 cites W2087184140 @default.
- W2103072677 cites W2088379678 @default.
- W2103072677 cites W2091396616 @default.
- W2103072677 cites W2094142374 @default.
- W2103072677 cites W2107526333 @default.
- W2103072677 cites W2109745829 @default.
- W2103072677 cites W2116546720 @default.
- W2103072677 cites W2118283772 @default.
- W2103072677 cites W2118965406 @default.
- W2103072677 cites W2120599642 @default.
- W2103072677 cites W2127525870 @default.
- W2103072677 cites W2128275248 @default.
- W2103072677 cites W2141095211 @default.
- W2103072677 cites W2160574311 @default.
- W2103072677 cites W2167683385 @default.
- W2103072677 cites W2169484065 @default.
- W2103072677 cites W2172187417 @default.
- W2103072677 cites W220109606 @default.
- W2103072677 cites W22570928 @default.
- W2103072677 cites W2274675599 @default.
- W2103072677 cites W261714213 @default.
- W2103072677 cites W277117100 @default.
- W2103072677 cites W2775186493 @default.
- W2103072677 cites W300669465 @default.
- W2103072677 cites W305789059 @default.
- W2103072677 cites W344089625 @default.
- W2103072677 doi "https://doi.org/10.1002/jps.20509" @default.
- W2103072677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16447176" @default.
- W2103072677 hasPublicationYear "2006" @default.
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