FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103076102> ?p ?o ?g. }

• W2103076102 endingPage "1107" @default.
• W2103076102 startingPage "1100" @default.
• W2103076102 abstract "Renal amyloidosis is characterized by the pathologic deposition within glomeruli and/or interstitium of congophilic fibrils, most often composed of either immunoglobulin light chains or serum amyloid A-related protein and, less commonly, mutated forms of apolipoproteins AI or AII, lysozyme, fibrinogen, gelsolin, or transthyretin.Case series.10 patients with renal amyloidosis who had an amyloidogenic protein that was not identified using routine immunohistochemistry.Clinical, pathologic, biochemical, and genetic characteristics.Tandem mass spectrometry was used to analyze fibrils extracted from sections of formalin-fixed paraffin-embedded amyloid-containing kidney biopsy specimen blocks.Chemical analyses showed peptides corresponding to the carboxy-terminal portion of the leukocyte chemotactic factor 2 (LECT2) molecule. In addition, deposits were immunostained using an anti-human LECT2 monoclonal antibody. Plasma specimens were available from 2 individuals for whom LECT2 concentration in these samples was within the reference range. Additionally, in 4 of the cases analyzed at the molecular level, isolation of genomic DNA and polymerase chain reaction amplification of LECT2-encoding exons showed no mutations. However, all were homozygous for the G allele encoding valine at position 40 in the mature protein, a finding confirmed using restriction enzyme analysis of the polymorphic site.Causality is not addressed.Based on our studies, we posit that LECT2-associated renal amyloidosis represents a unique and perhaps not uncommon disease, especially in Mexican Americans. The pathogenesis, extent, and prognosis remain to be determined." @default.
• W2103076102 created "2016-06-24" @default.
• W2103076102 creator A5014741294 @default.
• W2103076102 creator A5051446842 @default.
• W2103076102 creator A5051471130 @default.
• W2103076102 creator A5052794093 @default.
• W2103076102 creator A5061735083 @default.
• W2103076102 creator A5073720570 @default.
• W2103076102 creator A5073979129 @default.
• W2103076102 date "2010-12-01" @default.
• W2103076102 modified "2023-10-01" @default.
• W2103076102 title "Leukocyte Chemotactic Factor 2 (LECT2)-Associated Renal Amyloidosis: A Case Series" @default.
• W2103076102 cites W1556901591 @default.
• W2103076102 cites W2018834846 @default.
• W2103076102 cites W2020834752 @default.
• W2103076102 cites W2041396684 @default.
• W2103076102 cites W2043033098 @default.
• W2103076102 cites W2043697415 @default.
• W2103076102 cites W2044322225 @default.
• W2103076102 cites W2053896857 @default.
• W2103076102 cites W2056078138 @default.
• W2103076102 cites W2066939558 @default.
• W2103076102 cites W2071134058 @default.
• W2103076102 cites W2074965778 @default.
• W2103076102 cites W2086023076 @default.
• W2103076102 cites W2112605100 @default.
• W2103076102 cites W2127915510 @default.
• W2103076102 cites W2157464785 @default.
• W2103076102 cites W2887124244 @default.
• W2103076102 cites W4240572343 @default.
• W2103076102 cites W4250499495 @default.
• W2103076102 doi "https://doi.org/10.1053/j.ajkd.2010.08.013" @default.
• W2103076102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2991509" @default.
• W2103076102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20951486" @default.
• W2103076102 hasPublicationYear "2010" @default.
• W2103076102 type Work @default.
• W2103076102 sameAs 2103076102 @default.
• W2103076102 citedByCount "69" @default.
• W2103076102 countsByYear W21030761022012 @default.
• W2103076102 countsByYear W21030761022013 @default.
• W2103076102 countsByYear W21030761022014 @default.
• W2103076102 countsByYear W21030761022015 @default.
• W2103076102 countsByYear W21030761022016 @default.
• W2103076102 countsByYear W21030761022017 @default.
• W2103076102 countsByYear W21030761022018 @default.
• W2103076102 countsByYear W21030761022019 @default.
• W2103076102 countsByYear W21030761022020 @default.
• W2103076102 countsByYear W21030761022021 @default.
• W2103076102 countsByYear W21030761022022 @default.
• W2103076102 countsByYear W21030761022023 @default.
• W2103076102 crossrefType "journal-article" @default.
• W2103076102 hasAuthorship W2103076102A5014741294 @default.
• W2103076102 hasAuthorship W2103076102A5051446842 @default.
• W2103076102 hasAuthorship W2103076102A5051471130 @default.
• W2103076102 hasAuthorship W2103076102A5052794093 @default.
• W2103076102 hasAuthorship W2103076102A5061735083 @default.
• W2103076102 hasAuthorship W2103076102A5073720570 @default.
• W2103076102 hasAuthorship W2103076102A5073979129 @default.
• W2103076102 hasBestOaLocation W21030761022 @default.
• W2103076102 hasConcept C126322002 @default.
• W2103076102 hasConcept C142724271 @default.
• W2103076102 hasConcept C153911025 @default.
• W2103076102 hasConcept C159654299 @default.
• W2103076102 hasConcept C203014093 @default.
• W2103076102 hasConcept C204232928 @default.
• W2103076102 hasConcept C2777633098 @default.
• W2103076102 hasConcept C2779551797 @default.
• W2103076102 hasConcept C2779951007 @default.
• W2103076102 hasConcept C2780091579 @default.
• W2103076102 hasConcept C36394416 @default.
• W2103076102 hasConcept C71924100 @default.
• W2103076102 hasConcept C86803240 @default.
• W2103076102 hasConceptScore W2103076102C126322002 @default.
• W2103076102 hasConceptScore W2103076102C142724271 @default.
• W2103076102 hasConceptScore W2103076102C153911025 @default.
• W2103076102 hasConceptScore W2103076102C159654299 @default.
• W2103076102 hasConceptScore W2103076102C203014093 @default.
• W2103076102 hasConceptScore W2103076102C204232928 @default.
• W2103076102 hasConceptScore W2103076102C2777633098 @default.
• W2103076102 hasConceptScore W2103076102C2779551797 @default.
• W2103076102 hasConceptScore W2103076102C2779951007 @default.
• W2103076102 hasConceptScore W2103076102C2780091579 @default.
• W2103076102 hasConceptScore W2103076102C36394416 @default.
• W2103076102 hasConceptScore W2103076102C71924100 @default.
• W2103076102 hasConceptScore W2103076102C86803240 @default.
• W2103076102 hasFunder F4320337351 @default.
• W2103076102 hasFunder F4320337357 @default.
• W2103076102 hasIssue "6" @default.
• W2103076102 hasLocation W21030761021 @default.
• W2103076102 hasLocation W21030761022 @default.
• W2103076102 hasLocation W21030761023 @default.
• W2103076102 hasLocation W21030761024 @default.
• W2103076102 hasOpenAccess W2103076102 @default.
• W2103076102 hasPrimaryLocation W21030761021 @default.
• W2103076102 hasRelatedWork W175787708 @default.
• W2103076102 hasRelatedWork W195534694 @default.
• W2103076102 hasRelatedWork W2018817647 @default.
• W2103076102 hasRelatedWork W2085115677 @default.

• next