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- W2103082119 abstract "ABSTRACT Two natural new compounds, pyrroline-2-one ( 1 ) and 2-(2-amino-3-methyl-butyrylamino)-3-(4-hydroxy-phenyl)-propionic acid ( 2 ), together with nine known compounds, iodinin ( 3 ), thymine ( 4 ), N -(2-hydroxy-phenyl)-acetamide ( 5 ), ( Z )-pulchellalactam ( 6 ), uracil ( 7 ), nicotinic acid ( 8 ), nicotiamide ( 9 ); p -nitrophenol ( 10 ) and indole 3-carboxylic acid ( 11 ), all were isolated from the EtOAc extract of the culture broth of a new actinomycete Acrocarpospora sp. strain, FIRDI 001. The structures were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. Furthermore, the isolated compounds were subjected to evaluate the antimicrobial activity. Compounds 2 , 3 and 10 showed antimicrobial activity. The active metabolite, iodinin existed as a major metabolite in this study. Keywords : Acrocarpospora sp., Actinomycetes, Secondary metabolites, alkaloids, Iodinin, Antimicrobial activity. INTRODUCTION Microorganisms that can survive in diverse environments are of great interest for scientists. The actinomycetes, an order of filamentous bacteria, have proven to be a rich source of secondary metabolites that might be useful for the development of new pharmaceutical agents" @default.
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- W2103082119 date "2009-06-01" @default.
- W2103082119 modified "2023-10-18" @default.
- W2103082119 title "SECONDARY METABOLITES FROM THE CULTURE BROTH OF ACTINOMYCETE ACROCARPOSPORA SP. FIRDI 001 AND THEIR ANTIMICROBIAL ACTIVITY" @default.
- W2103082119 doi "https://doi.org/10.4067/s0717-97072009000200024" @default.
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