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- W2103089185 abstract "Introduction: Complex perioperative immunodysfunction occurs in patients with renal cell carcinoma undergoing surgery. Here, we report on the effect of preoperative treatment with interferon-α2a (IFN-α2a). Materials and Methods: 30 patients with a renal tumour received preoperative IFN-α2a for 6 days beginning 1 week before nephrectomy, 30 did not. Parameters of cellular and humoral immunity were measured in venous blood at various intervals using flow cytometry and ELISA. Endpoints included effects on immune parameters, toxicity, and survival. Results: Toxicity was grade 1 in 52%, 2 in 30%, and 3 in 4%. During IFN-α2a administration, leukocytes, monocytes, granulocytes, B-cell marker CD19, activation markers, CD4+CD25+ regulatory T-cells, and vascular endothelial growth factor (VEGF) dropped significantly, but no difference was observed in T-cell and natural killer (NK)-cell markers, and IL-10. Postoperatively, T-cell and activation markers decreased in both groups, but CD4, CD28, IL-6, IL-10, and HLA-DR alterations were significantly less accentuated in patients who had been treated with IFN-α2a. After a median follow-up of 23 months, survival did not differ between the groups (p = 0.54). Conclusions: Perioperative immunodysfunction can be modulated by preoperative administration of IFN- α2a. IFN-α2a decreased the level of VEGF and CD4+CD25+ regulatory T-cells implicating a potential combination with tyrosine kinase inhibitors and vaccines." @default.
- W2103089185 created "2016-06-24" @default.
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- W2103089185 date "2008-01-01" @default.
- W2103089185 modified "2023-10-17" @default.
- W2103089185 title "Pretreatment with Interferon-a2a Modulates Perioperative Immunodysfunction in Patients with Renal Cell Carcinoma" @default.
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- W2103089185 doi "https://doi.org/10.1159/000112214" @default.
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