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- W2103104057 abstract "The fungal polyketide lovastatin is a cholesterol lowering agent that is an immediate precursor to a multi-billion dollar drug, simvastatin (Zocor™). Lovastatin is produced by an iterative type I polyketide synthase known as LovB and a partner enoyl reductase (LovC). There is evidence that a Diels-Alderase enzyme activity is utilized in its biosynthesis. This review examines the biosynthesis of lovastatin, as well as of compactin, equisetin, cytochalasins, and solanapyrones, which are other structurally related polyketides that appear to utilize a Diels-Alderase. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 755–763, 2010." @default.
- W2103104057 created "2016-06-24" @default.
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- W2103104057 date "2010-06-23" @default.
- W2103104057 modified "2023-09-29" @default.
- W2103104057 title "Biosynthesis of lovastatin and related metabolites formed by fungal iterative PKS enzymes" @default.
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- W2103104057 doi "https://doi.org/10.1002/bip.21428" @default.
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