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• W2103104946 abstract "This study investigated whether CYP1B1 gene expression was associated with blood lipids levels. Workers from a municipal waste incineration plant in Taiwan participated in a questionnaire survey and physical examination and provided fasting blood samples for blood lipid analysis. CYP1B1 gene expression in workers' leukocytes was determined with the real-time reverse transcriptase polymerase chain reaction method, and 112 workers were categorized into three groups (low-, medium-, and high-expression) by their relative CYP1B1 gene expression levels. Multiple regression analyses were used to assess the association between blood lipid parameter and CYP1B1 expression. High-density lipoprotein (HDL) cholesterol was significantly lower in the high CYP1B1 expression group than in the low- and medium-expression groups (parameter estimate [standard error] = −7.16 [2.42] and −7.02 [2.46] mg/dL, respectively), after controlling for age, sex, CYP1B1 genotype, duration of employment, current number of cigarettes smoked per day, current alcohol drinking status, and body mass index. Triglycerides, low-density lipoprotein (LDL), and total cholesterol were not significantly different among the CYP1B1 expression groups. Furthermore, workers carrying the CYP1B1∗3 allele had significantly higher mean HDL, LDL, and total cholesterol, respectively, than those with CYP1B1∗1/∗1. CYP1B1 expression was associated with decreased HDL cholesterol levels in incinerator workers." @default.
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• W2103104946 date "2008-10-01" @default.
• W2103104946 modified "2023-09-23" @default.
• W2103104946 title "Association of Cytochrome P450 1B1 Gene Expression in Peripheral Leukocytes with Blood Lipid Levels in Waste Incinerator Workers" @default.
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• W2103104946 doi "https://doi.org/10.1016/j.annepidem.2008.05.002" @default.
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