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- W2103106665 abstract "Risk of immune thrombocytopenic purpura after measles-mumps-rubella immunization in children . France E. K., Glanz J., Xu S., Hambidge S., Yamasaki K., Black S. B., Marcy M., Mullooly J. P., Jackson L. A., Nordin J., Belongia E. A., Hohman K., Chen R. T. & Davis R. , for the Vaccine Safety Datalink Team ( 2008 ) Pediatrics , 121 , e687 – e692 . DOI: 10.1542/peds.2007-1578 . Background The measles-mumps-rubella vaccine has been associated with immune thrombocytopenia purpura in two small studies.Methods By using the Vaccine Safety Datalink, we identified measles-mumps-rubella-vaccinated children aged 1 to 18 years. A case of immune thrombocytopenia purpura was defined as a patient with a platelet count of ≤50 000/µL with clinical bleeding and normal red and white blood cell indices. The immune thrombocytopenia purpura incidence rates during exposed (42 days after vaccination) and unexposed time periods were determined. A retrospective cohort of vaccinated children was used to determine incident rate ratios for children aged 1 to 18 years, 12 to 23 months and 12 to 15 months.Results A total of 1 036 689 children received 1 107 814 measles-mumps-rubella vaccinations; there were 259 confirmed patients with immune thrombocytopenia purpura. Because only five exposed cases occurred after age 2 years, analyses were limited to children aged 12 to 23 months. Exposed patients aged 12 to 23 months had lower median platelet counts than those who were unexposed and had similar median duration of illness (11 vs. 10 days). The incident rate ratio was highest for children aged 12 to 15 months at 7.10. The incident rate ratio for boys aged 12 to 15 months was 14.59, and the incident rate ratio for girls in the same age group was 3.22. Seventy-six per cent of immune thrombocytopenia purpura cases in children aged 12 to 23 months were attributable to measles-mumps-rubella vaccination. This vaccine causes one case of immune thrombocytopenia purpura per every 40 000 doses.Conclusion Measles-mumps-rubella vaccine that is given in the second year of life is associated with an increased risk of immune thrombocytopenia purpura." @default.
- W2103106665 created "2016-06-24" @default.
- W2103106665 date "2008-07-01" @default.
- W2103106665 modified "2023-09-25" @default.
- W2103106665 title "Risk of immune thrombocytopenic purpura after measles-mumps-rubella immunization in children" @default.
- W2103106665 doi "https://doi.org/10.1111/j.1365-2214.2008.00864_6.x" @default.
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