FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103107412> ?p ?o ?g. }

• W2103107412 endingPage "231" @default.
• W2103107412 startingPage "223" @default.
• W2103107412 abstract "ABSTRACT Objectives: Increased morbidity and mortality in critically ill obese patients may result from an exaggerated inflammatory response and/or a diminished effectiveness of routine therapeutic strategies used in the critical care setting. The objectives of this study were to compare the effectiveness of hypertonic saline (HTS) resuscitation in obese and lean mice with sepsis and to address potential mechanisms underlying HTS‐mediated protection against the inflammatory and microvascular responses to sepsis. Methods: Intravital videomicroscopy was used to monitor and quantify the adhesion of platelets and leukocytes in the brain microcirculation of WT (C57 Bl/6) and ob/ob (B6.V‐ Lepob /J) mice subjected to cecal ligation and puncture (CLP) and resuscitated with either normal saline or HTS. The dual radiolabeled monoclonal antibody method was used to measure P‐selectin expression in the microcirculation, while the sepsis‐induced behavioral deficit was quantified using a multicompartment chamber test. Results: HTS attenuated the accumulation of adherent leukocytes and platelets and the behavioral deficit observed at 4 h after CLP in both WT and ob/ob mice. CLP‐induced upregulation of P‐selectin in the brain microcirculation was attenuated by HTS in ob/ob , but not in lean, mice. Conclusion: HTS exerts significant anti‐inflammatory and anti‐thrombogenic actions in obese septic mice. These responses may be related to the inhibitory effect of HTS on sepsis‐induced P‐selectin expression." @default.
• W2103107412 created "2016-06-24" @default.
• W2103107412 creator A5001996007 @default.
• W2103107412 creator A5038338463 @default.
• W2103107412 creator A5068048939 @default.
• W2103107412 creator A5086177582 @default.
• W2103107412 date "2007-03-04" @default.
• W2103107412 modified "2023-10-12" @default.
• W2103107412 title "Hypertonic Saline and the Cerebral Microcirculation in Obese Septic Mice" @default.
• W2103107412 cites W123715827 @default.
• W2103107412 cites W1875918201 @default.
• W2103107412 cites W1966698271 @default.
• W2103107412 cites W1973477746 @default.
• W2103107412 cites W1980717583 @default.
• W2103107412 cites W1981511179 @default.
• W2103107412 cites W1983080042 @default.
• W2103107412 cites W1990102152 @default.
• W2103107412 cites W1996890170 @default.
• W2103107412 cites W2004601475 @default.
• W2103107412 cites W2009852383 @default.
• W2103107412 cites W2015531285 @default.
• W2103107412 cites W2015591615 @default.
• W2103107412 cites W2018331304 @default.
• W2103107412 cites W2033492921 @default.
• W2103107412 cites W2046003585 @default.
• W2103107412 cites W2048762900 @default.
• W2103107412 cites W2049927822 @default.
• W2103107412 cites W2050169733 @default.
• W2103107412 cites W2055437345 @default.
• W2103107412 cites W2065269562 @default.
• W2103107412 cites W2080418085 @default.
• W2103107412 cites W2082621329 @default.
• W2103107412 cites W2085208748 @default.
• W2103107412 cites W2091424052 @default.
• W2103107412 cites W2094209772 @default.
• W2103107412 cites W2094711810 @default.
• W2103107412 cites W2136208369 @default.
• W2103107412 cites W2136795522 @default.
• W2103107412 cites W2138220577 @default.
• W2103107412 cites W2139152961 @default.
• W2103107412 cites W2145577370 @default.
• W2103107412 cites W2152384936 @default.
• W2103107412 cites W2160066171 @default.
• W2103107412 cites W2160691650 @default.
• W2103107412 cites W2165135332 @default.
• W2103107412 cites W2170989423 @default.
• W2103107412 cites W2217215084 @default.
• W2103107412 cites W2282977891 @default.
• W2103107412 cites W2322121630 @default.
• W2103107412 cites W2550507245 @default.
• W2103107412 cites W4376849766 @default.
• W2103107412 doi "https://doi.org/10.1080/10739680601139153" @default.
• W2103107412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17454674" @default.
• W2103107412 hasPublicationYear "2007" @default.
• W2103107412 type Work @default.
• W2103107412 sameAs 2103107412 @default.
• W2103107412 citedByCount "24" @default.
• W2103107412 countsByYear W21031074122012 @default.
• W2103107412 countsByYear W21031074122013 @default.
• W2103107412 countsByYear W21031074122014 @default.
• W2103107412 countsByYear W21031074122015 @default.
• W2103107412 countsByYear W21031074122016 @default.
• W2103107412 countsByYear W21031074122017 @default.
• W2103107412 countsByYear W21031074122018 @default.
• W2103107412 countsByYear W21031074122019 @default.
• W2103107412 countsByYear W21031074122021 @default.
• W2103107412 crossrefType "journal-article" @default.
• W2103107412 hasAuthorship W2103107412A5001996007 @default.
• W2103107412 hasAuthorship W2103107412A5038338463 @default.
• W2103107412 hasAuthorship W2103107412A5068048939 @default.
• W2103107412 hasAuthorship W2103107412A5086177582 @default.
• W2103107412 hasConcept C126322002 @default.
• W2103107412 hasConcept C12722491 @default.
• W2103107412 hasConcept C203014093 @default.
• W2103107412 hasConcept C2776914184 @default.
• W2103107412 hasConcept C2777397205 @default.
• W2103107412 hasConcept C2778165595 @default.
• W2103107412 hasConcept C2778384902 @default.
• W2103107412 hasConcept C2859252 @default.
• W2103107412 hasConcept C3017567848 @default.
• W2103107412 hasConcept C42219234 @default.
• W2103107412 hasConcept C71924100 @default.
• W2103107412 hasConcept C89560881 @default.
• W2103107412 hasConceptScore W2103107412C126322002 @default.
• W2103107412 hasConceptScore W2103107412C12722491 @default.
• W2103107412 hasConceptScore W2103107412C203014093 @default.
• W2103107412 hasConceptScore W2103107412C2776914184 @default.
• W2103107412 hasConceptScore W2103107412C2777397205 @default.
• W2103107412 hasConceptScore W2103107412C2778165595 @default.
• W2103107412 hasConceptScore W2103107412C2778384902 @default.
• W2103107412 hasConceptScore W2103107412C2859252 @default.
• W2103107412 hasConceptScore W2103107412C3017567848 @default.
• W2103107412 hasConceptScore W2103107412C42219234 @default.
• W2103107412 hasConceptScore W2103107412C71924100 @default.
• W2103107412 hasConceptScore W2103107412C89560881 @default.
• W2103107412 hasIssue "3" @default.
• W2103107412 hasLocation W21031074121 @default.
• W2103107412 hasLocation W21031074122 @default.

• next