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• W2103111390 startingPage "13" @default.
• W2103111390 abstract "In Saccharomyces cerevisiae, clathrin is necessary for localization of trans-Golgi network (TGN) membrane proteins, a process that involves cycling of TGN proteins between the TGN and endosomes. To characterize further TGN protein localization, we applied a screen for mutations that cause severe growth defects in combination with a temperature-sensitive clathrin heavy chain. This screen yielded a mutant allele of RIC1. Cells carrying a deletion of RIC1 (ric1Δ) mislocalize TGN membrane proteins Kex2p and Vps10p to the vacuole. Delivery to the vacuole occurs in ric1Δ cells also harboringend3Δ to block endocytosis, indicative of a defect in retrieval to the TGN rather than sorting to endosomes.SYS1, originally discovered as a multicopy suppressor of defects caused by the absence of the Rab GTPase YPT6, was identified as a multicopy suppressor of ric1Δ. Further comparison of ric1Δ and ypt6Δ cells demonstrated identical phenotypes. Multicopy plasmids expressing v-SNAREs Gos1p or Ykt6p, but not other v- and t-SNAREs, partially suppressed phenotypes of ric1Δ andypt6Δ cells. SLY1–20, a dominant activator of the cis-Golgi network t-SNARE Sed5p, also functioned as a multicopy suppressor. Because Gos1p and Ykt6p interact with Sed5p, these results raise the possibility that TGN membrane protein localization requires Ric1p- and Ypt6p-dependent retrieval to the cis-Golgi network." @default.
• W2103111390 created "2016-06-24" @default.
• W2103111390 creator A5044989399 @default.
• W2103111390 creator A5061726557 @default.
• W2103111390 creator A5068824412 @default.
• W2103111390 date "2001-01-01" @default.
• W2103111390 modified "2023-10-17" @default.
• W2103111390 title "Ric1p and the Ypt6p GTPase Function in a Common Pathway Required for Localization of<i>Trans</i>-Golgi Network Membrane Proteins" @default.
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• W2103111390 doi "https://doi.org/10.1091/mbc.12.1.13" @default.
• W2103111390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/30564" @default.
• W2103111390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11160819" @default.
• W2103111390 hasPublicationYear "2001" @default.

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