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- W2103113342 abstract "Surfactants carrying fluorocarbon chains hold great promise as gentle alternatives to conventional hydrocarbon-based detergents for the solubilization and handling of integral membrane proteins. However, their inertness towards lipid bilayer membranes has limited the usefulness of fluorinated surfactants in situations where detergent-like activity is required. We demonstrate that fluorination does not necessarily preclude detergency, as exemplified by a fluorinated octyl maltoside derivative termed F6 OM. This nonionic compound readily interacts with and completely solubilizes phospholipid vesicles in a manner reminiscent of conventional detergents without, however, compromising membrane order at subsolubilizing concentrations. Owing to this mild and unusual mode of detergency, F6 OM outperforms a lipophobic fluorinated surfactant in chaperoning the functional refolding of an integral membrane enzyme by promoting bilayer insertion in the absence of micelles." @default.
- W2103113342 created "2016-06-24" @default.
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- W2103113342 date "2015-03-09" @default.
- W2103113342 modified "2023-10-11" @default.
- W2103113342 title "A Fluorinated Detergent for Membrane-Protein Applications" @default.
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- W2103113342 doi "https://doi.org/10.1002/anie.201412359" @default.
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