Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103114711> ?p ?o ?g. }
- W2103114711 abstract "Antipsychotic drugs have thus far focused on dopaminergic antagonism at the D2 receptors, as counteracting the hyperdopaminergia in nigrostriatal and mesolimbic projections has been considered mandatory for the antipsychotic action of the drugs. Current drugs effectively target the positive symptoms of psychosis such as hallucinations and delusions in the majority of patients, whereas effect sizes are smaller for negative symptoms and cognitive dysfunctions. With the understanding that neurocognitive dysfunction associated with schizophrenia have a greater impact on functional outcome than the positive symptoms, the focus in pharmacotherapy for schizophrenia has shifted to the potential effect of future drugs on cognitive enhancement. A major obstacle is, however, that the biological underpinnings of cognitive dysfunction remain largely unknown. With the availability of increasingly sophisticated techniques in molecular biology and brain imaging, this situation is about to change with major advances being made in identifying the neuronal substrates underlying schizophrenia, and putative pro-cognitive drug targets may be revealed. In relation to cognitive effects, this review focuses on evidence from basic neuroscience and clinical studies, taking two separate perspectives. One perspective is the identification of previously under-recognized treatment targets for existing antipsychotic drugs, including myelination and mediators of inflammation. A second perspective is the development of new drugs or novel treatment targets for well-known drugs, which act on recently discovered treatment targets for cognitive enhancement, and which may complement the existing drugs. This might pave the way for personalized treatment regimens for patients with schizophrenia aimed at improved functional outcome. The review also aims at identifying major current constraints for pro-cognitive drug development for patients with schizophrenia." @default.
- W2103114711 created "2016-06-24" @default.
- W2103114711 creator A5008276160 @default.
- W2103114711 creator A5012930529 @default.
- W2103114711 creator A5018835541 @default.
- W2103114711 creator A5021113966 @default.
- W2103114711 creator A5024510971 @default.
- W2103114711 creator A5052870289 @default.
- W2103114711 creator A5061830368 @default.
- W2103114711 creator A5081307524 @default.
- W2103114711 date "2014-01-01" @default.
- W2103114711 modified "2023-10-11" @default.
- W2103114711 title "A Critical Review of Pro-Cognitive Drug Targets in Psychosis: Convergence on Myelination and Inflammation" @default.
- W2103114711 cites W1489927176 @default.
- W2103114711 cites W150090035 @default.
- W2103114711 cites W1518890501 @default.
- W2103114711 cites W1519234019 @default.
- W2103114711 cites W1531385680 @default.
- W2103114711 cites W1616286551 @default.
- W2103114711 cites W1898504652 @default.
- W2103114711 cites W1902399643 @default.
- W2103114711 cites W1903575196 @default.
- W2103114711 cites W1972553460 @default.
- W2103114711 cites W1972578501 @default.
- W2103114711 cites W1977070136 @default.
- W2103114711 cites W1978238793 @default.
- W2103114711 cites W1980854607 @default.
- W2103114711 cites W1982474832 @default.
- W2103114711 cites W1983074248 @default.
- W2103114711 cites W1986484493 @default.
- W2103114711 cites W1987248281 @default.
- W2103114711 cites W1987857702 @default.
- W2103114711 cites W1990916016 @default.
- W2103114711 cites W1995317998 @default.
- W2103114711 cites W1996580716 @default.
- W2103114711 cites W2000169164 @default.
- W2103114711 cites W2004006028 @default.
- W2103114711 cites W2004065519 @default.
- W2103114711 cites W2008020964 @default.
- W2103114711 cites W2008471332 @default.
- W2103114711 cites W2009832071 @default.
- W2103114711 cites W2010122299 @default.
- W2103114711 cites W2010137148 @default.
- W2103114711 cites W2011541946 @default.
- W2103114711 cites W2012834841 @default.
- W2103114711 cites W2014780789 @default.
- W2103114711 cites W2017141784 @default.
- W2103114711 cites W2017661386 @default.
- W2103114711 cites W2018362056 @default.
- W2103114711 cites W2019810554 @default.
- W2103114711 cites W2020844317 @default.
- W2103114711 cites W2022433310 @default.
- W2103114711 cites W2022616811 @default.
- W2103114711 cites W2023274187 @default.
- W2103114711 cites W2026751111 @default.
- W2103114711 cites W2027144452 @default.
- W2103114711 cites W2027312796 @default.
- W2103114711 cites W2027864582 @default.
- W2103114711 cites W2028370746 @default.
- W2103114711 cites W2029543879 @default.
- W2103114711 cites W2030396834 @default.
- W2103114711 cites W2030765669 @default.
- W2103114711 cites W2035938722 @default.
- W2103114711 cites W2037807133 @default.
- W2103114711 cites W2039335406 @default.
- W2103114711 cites W2041333773 @default.
- W2103114711 cites W2042755650 @default.
- W2103114711 cites W2043162328 @default.
- W2103114711 cites W2045638929 @default.
- W2103114711 cites W2047975465 @default.
- W2103114711 cites W2049854720 @default.
- W2103114711 cites W2050584458 @default.
- W2103114711 cites W2052480734 @default.
- W2103114711 cites W2058711140 @default.
- W2103114711 cites W2058819186 @default.
- W2103114711 cites W2059631901 @default.
- W2103114711 cites W2059764671 @default.
- W2103114711 cites W2060050678 @default.
- W2103114711 cites W2060953248 @default.
- W2103114711 cites W2061796139 @default.
- W2103114711 cites W2063765492 @default.
- W2103114711 cites W2066738717 @default.
- W2103114711 cites W2067732599 @default.
- W2103114711 cites W2069620520 @default.
- W2103114711 cites W2072058525 @default.
- W2103114711 cites W2072328883 @default.
- W2103114711 cites W2075160582 @default.
- W2103114711 cites W2075578206 @default.
- W2103114711 cites W2076372282 @default.
- W2103114711 cites W2078881206 @default.
- W2103114711 cites W2080092700 @default.
- W2103114711 cites W2082372626 @default.
- W2103114711 cites W2084531842 @default.
- W2103114711 cites W2084588595 @default.
- W2103114711 cites W2084722042 @default.
- W2103114711 cites W2085390488 @default.
- W2103114711 cites W2086902897 @default.
- W2103114711 cites W2091960711 @default.
- W2103114711 cites W2094808087 @default.
- W2103114711 cites W2094923038 @default.