FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103116278> ?p ?o ?g. }

• W2103116278 endingPage "1498" @default.
• W2103116278 startingPage "1489" @default.
• W2103116278 abstract "Prolonged deprivation of food induces dramatic changes in mammalian metabolism, including the release of large amounts of fatty acids from the adipose tissue, followed by their oxidation in the liver. The nuclear receptor known as peroxisome proliferator-activated receptor alpha (PPARalpha) was found to play a role in regulating mitochondrial and peroxisomal fatty acid oxidation, suggesting that PPARalpha may be involved in the transcriptional response to fasting. To investigate this possibility, PPARalpha-null mice were subjected to a high fat diet or to fasting, and their responses were compared with those of wild-type mice. PPARalpha-null mice chronically fed a high fat diet showed a massive accumulation of lipid in their livers. A similar phenotype was noted in PPARalpha-null mice fasted for 24 hours, who also displayed severe hypoglycemia, hypoketonemia, hypothermia, and elevated plasma free fatty acid levels, indicating a dramatic inhibition of fatty acid uptake and oxidation. It is shown that to accommodate the increased requirement for hepatic fatty acid oxidation, PPARalpha mRNA is induced during fasting in wild-type mice. The data indicate that PPARalpha plays a pivotal role in the management of energy stores during fasting. By modulating gene expression, PPARalpha stimulates hepatic fatty acid oxidation to supply substrates that can be metabolized by other tissues." @default.
• W2103116278 created "2016-06-24" @default.
• W2103116278 creator A5015220851 @default.
• W2103116278 creator A5028342693 @default.
• W2103116278 creator A5037086101 @default.
• W2103116278 creator A5067434963 @default.
• W2103116278 creator A5073932699 @default.
• W2103116278 creator A5081069263 @default.
• W2103116278 date "1999-06-01" @default.
• W2103116278 modified "2023-10-17" @default.
• W2103116278 title "Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting" @default.
• W2103116278 cites W1633340712 @default.
• W2103116278 cites W1639924204 @default.
• W2103116278 cites W1813630464 @default.
• W2103116278 cites W188774652 @default.
• W2103116278 cites W189878058 @default.
• W2103116278 cites W1942020611 @default.
• W2103116278 cites W1961653620 @default.
• W2103116278 cites W1975884121 @default.
• W2103116278 cites W1976621212 @default.
• W2103116278 cites W1981101682 @default.
• W2103116278 cites W1981152838 @default.
• W2103116278 cites W1985683101 @default.
• W2103116278 cites W1994908701 @default.
• W2103116278 cites W2002519246 @default.
• W2103116278 cites W2003859756 @default.
• W2103116278 cites W2005126581 @default.
• W2103116278 cites W2016298359 @default.
• W2103116278 cites W2016603091 @default.
• W2103116278 cites W2027874598 @default.
• W2103116278 cites W2031545586 @default.
• W2103116278 cites W2031846075 @default.
• W2103116278 cites W2037766435 @default.
• W2103116278 cites W2039520448 @default.
• W2103116278 cites W2041811148 @default.
• W2103116278 cites W2047982128 @default.
• W2103116278 cites W2048761802 @default.
• W2103116278 cites W2056185391 @default.
• W2103116278 cites W2063589730 @default.
• W2103116278 cites W2071249061 @default.
• W2103116278 cites W2083161103 @default.
• W2103116278 cites W2087647782 @default.
• W2103116278 cites W2102106861 @default.
• W2103116278 cites W2110438479 @default.
• W2103116278 cites W2116470680 @default.
• W2103116278 cites W2119016586 @default.
• W2103116278 cites W2120432009 @default.
• W2103116278 cites W2121914083 @default.
• W2103116278 cites W2123662065 @default.
• W2103116278 cites W2124702739 @default.
• W2103116278 cites W2134270245 @default.
• W2103116278 cites W2134920653 @default.
• W2103116278 cites W2139002144 @default.
• W2103116278 cites W2140038597 @default.
• W2103116278 cites W2140161647 @default.
• W2103116278 cites W2153321120 @default.
• W2103116278 cites W2158550325 @default.
• W2103116278 cites W2159883603 @default.
• W2103116278 cites W2171119762 @default.
• W2103116278 cites W2278067035 @default.
• W2103116278 cites W2868496 @default.
• W2103116278 doi "https://doi.org/10.1172/jci6223" @default.
• W2103116278 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/408372" @default.
• W2103116278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10359558" @default.
• W2103116278 hasPublicationYear "1999" @default.
• W2103116278 type Work @default.
• W2103116278 sameAs 2103116278 @default.
• W2103116278 citedByCount "1516" @default.
• W2103116278 countsByYear W21031162782012 @default.
• W2103116278 countsByYear W21031162782013 @default.
• W2103116278 countsByYear W21031162782014 @default.
• W2103116278 countsByYear W21031162782015 @default.
• W2103116278 countsByYear W21031162782016 @default.
• W2103116278 countsByYear W21031162782017 @default.
• W2103116278 countsByYear W21031162782018 @default.
• W2103116278 countsByYear W21031162782019 @default.
• W2103116278 countsByYear W21031162782020 @default.
• W2103116278 countsByYear W21031162782021 @default.
• W2103116278 countsByYear W21031162782022 @default.
• W2103116278 countsByYear W21031162782023 @default.
• W2103116278 crossrefType "journal-article" @default.
• W2103116278 hasAuthorship W2103116278A5015220851 @default.
• W2103116278 hasAuthorship W2103116278A5028342693 @default.
• W2103116278 hasAuthorship W2103116278A5037086101 @default.
• W2103116278 hasAuthorship W2103116278A5067434963 @default.
• W2103116278 hasAuthorship W2103116278A5073932699 @default.
• W2103116278 hasAuthorship W2103116278A5081069263 @default.
• W2103116278 hasBestOaLocation W21031162781 @default.
• W2103116278 hasConcept C104317684 @default.
• W2103116278 hasConcept C126322002 @default.
• W2103116278 hasConcept C127078168 @default.
• W2103116278 hasConcept C134018914 @default.
• W2103116278 hasConcept C141359234 @default.
• W2103116278 hasConcept C170493617 @default.
• W2103116278 hasConcept C171089720 @default.
• W2103116278 hasConcept C185592680 @default.
• W2103116278 hasConcept C187345961 @default.
• W2103116278 hasConcept C188413054 @default.

• next