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- W2103117763 abstract "Esmolol, a new cardioselective beta adrenergic blocker inhibits plasmacholinesterase activity in vitro. The concentration of esmolol hydrochloride that inhibits by 50 per cent the hydrolysis of 50.0 µnol·L−1 benzoylcholine hydrochloride by 1:200 diluted, heparinized pooled plasma of six healthy volunteers at 37° C and 240 nm, determined by the ultraviolet spectrophotometric method of Kalow, was 50 µmol·−1. Esmolol’s primary metabolite, 3-(4-(2-hydroxy-3-(isopropylamino)propoxy)-phenyllpropionic acid, had an l5 = 190 µnol·L−1 . The benzoylcholine hydrolysis rates in the plasma of ten patients who received an esmolol infusion of 500 µg·kg−1. min−1 for 4 minutes were 58.6 ± 6.2 µmol·hr−1·ml−1 (mean ± SE) before and 55.1 ± 6.6 µmol·hr−1·ml−1 after the infusion. The benzoylcholine hydrolysis rates in the plasma of ten patients who received an esmolol infusion of 500 µg·kg−1·min−1 for two minutes and 200 µg·kg−1·min−1 for an additional two minutes were 70.2 ± 8.9µmol·hr−1·ml−1 before and 69.1 ± 9.5 µmol·hr−1. ml−1 after the infusion. The pre- and post-infusion plasmacholinesterase activities were not significantly different. Since plasmacholinesterase is responsible for the hydrolysis of succinylcholine and that of the ester-type local anaesthetics this lack of in vivo interaction of esmolol with the hydrolysis of these drugs should be further confirmed by experiments with these combinations in man." @default.
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- W2103117763 date "1986-05-01" @default.
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- W2103117763 title "The inhibitory effect of esmolol on human plasmacholinesterase" @default.
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- W2103117763 doi "https://doi.org/10.1007/bf03010746" @default.
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