FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103121176> ?p ?o ?g. }

• W2103121176 endingPage "34" @default.
• W2103121176 startingPage "23" @default.
• W2103121176 abstract "Amphibians have a remarkable capacity for limb regeneration. Following a severe injury, there is complete regeneration with restoration of the patterning and cellular architecture of the amputated limb. While studies have focused on the structural anatomical changes during amphibian limb regeneration, the signaling mechanisms that govern cellular dedifferentiation and blastemal progenitors are unknown. Here, we demonstrate the temporal and spatial requirement for hedgehog (Hh) signaling and its hierarchical correlation with respect to Wnt signaling during newt limb regeneration. While the dedifferentiation process of mature lineages does not depend on Hh signaling, the proliferation and the migration of the dedifferentiated cells are dependent on Hh signaling. Temporally controlled chemical inactivation of the Hh pathway indicates that Hh-mediated antero-posterior (AP) specification occurs early during limb regeneration and that Hh is subsequently required for expansion of the blastemal progenitors. Inhibition of Hh signaling results in G0/G1 arrest with a concomitant reduction in S-phase and G2/M population in myogenic progenitors. Furthermore, Hh inhibition leads to reduced Pax7-positive cells and fewer regenerating fibers relative to control tissue. We demonstrate that activation of Wnt signaling rescues the inhibition of Hh pathway mainly by enhancing proliferative signals, possibly mediated through TCF4 activity. Collectively, our results demonstrate coordinated signaling of Hh and Wnt activities in regulating blastemal progenitors and their hierarchical positioning during limb regeneration." @default.
• W2103121176 created "2016-06-24" @default.
• W2103121176 creator A5000991811 @default.
• W2103121176 creator A5022788002 @default.
• W2103121176 creator A5036817888 @default.
• W2103121176 creator A5073599890 @default.
• W2103121176 creator A5078505715 @default.
• W2103121176 date "2012-11-01" @default.
• W2103121176 modified "2023-10-16" @default.
• W2103121176 title "Hedgehog and Wnt coordinate signaling in myogenic progenitors and regulate limb regeneration" @default.
• W2103121176 cites W1565817365 @default.
• W2103121176 cites W1583338361 @default.
• W2103121176 cites W1926761495 @default.
• W2103121176 cites W1972120726 @default.
• W2103121176 cites W1972979483 @default.
• W2103121176 cites W1977565455 @default.
• W2103121176 cites W1985207433 @default.
• W2103121176 cites W1988257487 @default.
• W2103121176 cites W1998271270 @default.
• W2103121176 cites W1998970920 @default.
• W2103121176 cites W1999604714 @default.
• W2103121176 cites W2002256459 @default.
• W2103121176 cites W2002391499 @default.
• W2103121176 cites W2006836569 @default.
• W2103121176 cites W2010070885 @default.
• W2103121176 cites W2017429680 @default.
• W2103121176 cites W2018622952 @default.
• W2103121176 cites W2019789997 @default.
• W2103121176 cites W2027909397 @default.
• W2103121176 cites W2030445959 @default.
• W2103121176 cites W2031233488 @default.
• W2103121176 cites W2036211290 @default.
• W2103121176 cites W2038515472 @default.
• W2103121176 cites W2043648485 @default.
• W2103121176 cites W2044228161 @default.
• W2103121176 cites W2046762811 @default.
• W2103121176 cites W2057921641 @default.
• W2103121176 cites W2063114980 @default.
• W2103121176 cites W2069666205 @default.
• W2103121176 cites W2072585512 @default.
• W2103121176 cites W2075317095 @default.
• W2103121176 cites W2081988909 @default.
• W2103121176 cites W2082417115 @default.
• W2103121176 cites W2083405476 @default.
• W2103121176 cites W2089494613 @default.
• W2103121176 cites W2096771882 @default.
• W2103121176 cites W2100250587 @default.
• W2103121176 cites W2105505995 @default.
• W2103121176 cites W2111763078 @default.
• W2103121176 cites W2117796397 @default.
• W2103121176 cites W2124593559 @default.
• W2103121176 cites W2128801071 @default.
• W2103121176 cites W2137755780 @default.
• W2103121176 cites W2147817030 @default.
• W2103121176 cites W2148627988 @default.
• W2103121176 cites W2149186578 @default.
• W2103121176 cites W2150761291 @default.
• W2103121176 cites W2151518299 @default.
• W2103121176 cites W2152224682 @default.
• W2103121176 cites W2160889747 @default.
• W2103121176 cites W2161282017 @default.
• W2103121176 cites W2165874498 @default.
• W2103121176 cites W2170149088 @default.
• W2103121176 cites W2387086685 @default.
• W2103121176 doi "https://doi.org/10.1016/j.ydbio.2012.07.033" @default.
• W2103121176 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3987681" @default.
• W2103121176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22902898" @default.
• W2103121176 hasPublicationYear "2012" @default.
• W2103121176 type Work @default.
• W2103121176 sameAs 2103121176 @default.
• W2103121176 citedByCount "49" @default.
• W2103121176 countsByYear W21031211762013 @default.
• W2103121176 countsByYear W21031211762014 @default.
• W2103121176 countsByYear W21031211762015 @default.
• W2103121176 countsByYear W21031211762016 @default.
• W2103121176 countsByYear W21031211762017 @default.
• W2103121176 countsByYear W21031211762018 @default.
• W2103121176 countsByYear W21031211762019 @default.
• W2103121176 countsByYear W21031211762020 @default.
• W2103121176 countsByYear W21031211762021 @default.
• W2103121176 countsByYear W21031211762022 @default.
• W2103121176 countsByYear W21031211762023 @default.
• W2103121176 crossrefType "journal-article" @default.
• W2103121176 hasAuthorship W2103121176A5000991811 @default.
• W2103121176 hasAuthorship W2103121176A5022788002 @default.
• W2103121176 hasAuthorship W2103121176A5036817888 @default.
• W2103121176 hasAuthorship W2103121176A5073599890 @default.
• W2103121176 hasAuthorship W2103121176A5078505715 @default.
• W2103121176 hasBestOaLocation W21031211761 @default.
• W2103121176 hasConcept C105702510 @default.
• W2103121176 hasConcept C137620995 @default.
• W2103121176 hasConcept C144024400 @default.
• W2103121176 hasConcept C149923435 @default.
• W2103121176 hasConcept C15729860 @default.
• W2103121176 hasConcept C171056886 @default.
• W2103121176 hasConcept C201750760 @default.
• W2103121176 hasConcept C2778539099 @default.
• W2103121176 hasConcept C28328180 @default.

• next