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- W2103123762 abstract "Abstract The stability of loperamide hydrochloride at 90 ± 0.2 °C in different pH solutions with various buffer species (acetate, phosphate and borate) at a constant buffer concentration of 0.1 M and ionic strength of 0.5 has been studied using a developed stability-indicating high-performance liquid chromatographic method. This analytical procedure shows a linear response range at concentrations of 2 to 10 μg/ml with a correlation coefficient greater than 0.99. The observed rate of degradation was founf to follow apparent first order kinetics with respect to loperamide hydrochloride. The maximum stability of loperamide hydrochloride was shown to be at an approximate pH of 4.5. The catalytic effect of specific acid-base and water on the degradation of loperamide hydrochloride aqueous solution was expected; however, general acid-base catalysis from different buffer species is possible but needs to be studied further." @default.
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- W2103123762 date "1989-04-01" @default.
- W2103123762 modified "2023-09-27" @default.
- W2103123762 title "Stability of loperamide hydrochloride in aqueous solutions as determined by high performance liquid chromatography" @default.
- W2103123762 cites W2077947585 @default.
- W2103123762 doi "https://doi.org/10.1016/0378-5173(89)90249-4" @default.
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