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- W2103126826 abstract "Japanese encephalitis virus (JEV), a flavivirus maintained in a zoonotic cycle and transmitted by the mosquito Culex tritaeniorhynchus, causes epidemics of encephalitis throughout much of Asia. Resident populations, including short- or long-term visitors to enzootic regions, are at risk of infection and disease. For the past several decades, killed viral vaccines prepared in tissue culture or mouse brain have been used effectively to immunize travelers and residents of enzootic countries. Cost, efficacy and safety concerns led to the development of a live-attenuated virus vaccine (SA14-14-2) and more recently, to the licensure in the USA, Europe, Canada, and Australia of a purified inactivated, tissue culture-based Japanese encephalitis vaccine (IXIARO®, referred to as IC51; Intercell AG, Vienna, Austria). In addition, a live-attenuated yellow fever–Japanese encephalitis chimeric vaccine (IMOJEV™, referred to as Japanese encephalitis-CV; Sanofi Pasteur, Lyon, France) was recently licensed in Australia and is under review in Thailand. A broad portfolio of safe and effective Japanese encephalitis vaccines has become available to meet the needs of at-risk populations; when appropriately delivered, these new vaccines should greatly diminish the burden of disease." @default.
- W2103126826 created "2016-06-24" @default.
- W2103126826 creator A5059606373 @default.
- W2103126826 creator A5077156970 @default.
- W2103126826 date "2011-03-01" @default.
- W2103126826 modified "2023-10-16" @default.
- W2103126826 title "New Japanese encephalitis vaccines: alternatives to production in mouse brain" @default.
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- W2103126826 doi "https://doi.org/10.1586/erv.11.7" @default.
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