FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103127735> ?p ?o ?g. }

• W2103127735 endingPage "407" @default.
• W2103127735 startingPage "401" @default.
• W2103127735 abstract "Three-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) are one of the most commonly prescribed classes of medications because of their proven cardiovascular benefits. However, statin intolerance occurs in 5% to 20% of patients. Understanding the basis for statin intolerance remains a key issue in preventive medicine.To evaluate the association of statin intolerance with hypothyroidism in a large integrated health care system, including its sex-specific relationship and subsequent statin rechallenge and prescription history.The Intermountain Healthcare electronic medical record database identified patients (n = 2686; males = 1276, females = 1410) with a documentation of intolerance (allergy) to at least 1 statin. Age and sex similar controls (n = 8103; males = 3892, females = 4211) were identified among patients prescribed statins without documented intolerance. Patients were evaluated for a history of hypothyroidism, development of hypothyroidism, and statin prescription history up to 5 years of follow-up.A total of 30.2% patients (210 males, 16.5%; 602 females, 42.7%) with statin intolerance had a history of hypothyroidism compared with 21.5% of statin-tolerant patients (475 males, 12.2%; 1266 females, 30.1%), for an odds ratio (OR) in the total population of 1.49 (95% confidence interval [CI] 1.34-1.65; P < .0001); in males, OR was 1.29 (CI 1.07-1.55; P = .001); in females, OR was 1.60 (CI 1.41-1.82; P < .0001). During follow-up, patients with statin intolerance and hypothyroidism were less likely to be on a statin than their statin-intolerant counterparts without hypothyroidism (hazard ratio 0.84; 95% CI 0.75-0.94; P = .002).Hypothyroidism is more prevalent in those with statin intolerance, both in males and, especially, in females. People with hypothyroidism are less likely to have a prescription for a statin at follow-up than those without hypothyroidism." @default.
• W2103127735 created "2016-06-24" @default.
• W2103127735 creator A5002290002 @default.
• W2103127735 creator A5038927942 @default.
• W2103127735 creator A5067666881 @default.
• W2103127735 creator A5071011669 @default.
• W2103127735 creator A5077701573 @default.
• W2103127735 creator A5085672618 @default.
• W2103127735 creator A5089940190 @default.
• W2103127735 date "2014-07-01" @default.
• W2103127735 modified "2023-10-07" @default.
• W2103127735 title "Hypothyroidism as a risk factor for statin intolerance" @default.
• W2103127735 cites W123384717 @default.
• W2103127735 cites W16273785 @default.
• W2103127735 cites W1982569305 @default.
• W2103127735 cites W1996730762 @default.
• W2103127735 cites W2004141960 @default.
• W2103127735 cites W2004955337 @default.
• W2103127735 cites W2010033213 @default.
• W2103127735 cites W2021586491 @default.
• W2103127735 cites W2022243356 @default.
• W2103127735 cites W2039350980 @default.
• W2103127735 cites W2039443222 @default.
• W2103127735 cites W2053082244 @default.
• W2103127735 cites W2056440002 @default.
• W2103127735 cites W2064595979 @default.
• W2103127735 cites W2070126347 @default.
• W2103127735 cites W2107542839 @default.
• W2103127735 cites W2122733513 @default.
• W2103127735 cites W2140936682 @default.
• W2103127735 cites W2151046514 @default.
• W2103127735 cites W2165673279 @default.
• W2103127735 cites W2167825981 @default.
• W2103127735 cites W2475064515 @default.
• W2103127735 doi "https://doi.org/10.1016/j.jacl.2014.05.005" @default.
• W2103127735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25110221" @default.
• W2103127735 hasPublicationYear "2014" @default.
• W2103127735 type Work @default.
• W2103127735 sameAs 2103127735 @default.
• W2103127735 citedByCount "21" @default.
• W2103127735 countsByYear W21031277352014 @default.
• W2103127735 countsByYear W21031277352015 @default.
• W2103127735 countsByYear W21031277352016 @default.
• W2103127735 countsByYear W21031277352017 @default.
• W2103127735 countsByYear W21031277352018 @default.
• W2103127735 countsByYear W21031277352019 @default.
• W2103127735 countsByYear W21031277352020 @default.
• W2103127735 countsByYear W21031277352022 @default.
• W2103127735 countsByYear W21031277352023 @default.
• W2103127735 crossrefType "journal-article" @default.
• W2103127735 hasAuthorship W2103127735A5002290002 @default.
• W2103127735 hasAuthorship W2103127735A5038927942 @default.
• W2103127735 hasAuthorship W2103127735A5067666881 @default.
• W2103127735 hasAuthorship W2103127735A5071011669 @default.
• W2103127735 hasAuthorship W2103127735A5077701573 @default.
• W2103127735 hasAuthorship W2103127735A5085672618 @default.
• W2103127735 hasAuthorship W2103127735A5089940190 @default.
• W2103127735 hasConcept C126322002 @default.
• W2103127735 hasConcept C156957248 @default.
• W2103127735 hasConcept C206179267 @default.
• W2103127735 hasConcept C207103383 @default.
• W2103127735 hasConcept C2426938 @default.
• W2103127735 hasConcept C2776839432 @default.
• W2103127735 hasConcept C2908647359 @default.
• W2103127735 hasConcept C44249647 @default.
• W2103127735 hasConcept C71924100 @default.
• W2103127735 hasConcept C98274493 @default.
• W2103127735 hasConcept C99454951 @default.
• W2103127735 hasConceptScore W2103127735C126322002 @default.
• W2103127735 hasConceptScore W2103127735C156957248 @default.
• W2103127735 hasConceptScore W2103127735C206179267 @default.
• W2103127735 hasConceptScore W2103127735C207103383 @default.
• W2103127735 hasConceptScore W2103127735C2426938 @default.
• W2103127735 hasConceptScore W2103127735C2776839432 @default.
• W2103127735 hasConceptScore W2103127735C2908647359 @default.
• W2103127735 hasConceptScore W2103127735C44249647 @default.
• W2103127735 hasConceptScore W2103127735C71924100 @default.
• W2103127735 hasConceptScore W2103127735C98274493 @default.
• W2103127735 hasConceptScore W2103127735C99454951 @default.
• W2103127735 hasIssue "4" @default.
• W2103127735 hasLocation W21031277351 @default.
• W2103127735 hasLocation W21031277352 @default.
• W2103127735 hasOpenAccess W2103127735 @default.
• W2103127735 hasPrimaryLocation W21031277351 @default.
• W2103127735 hasRelatedWork W1971875340 @default.
• W2103127735 hasRelatedWork W2022392719 @default.
• W2103127735 hasRelatedWork W2099596243 @default.
• W2103127735 hasRelatedWork W2804529914 @default.
• W2103127735 hasRelatedWork W2887472478 @default.
• W2103127735 hasRelatedWork W3017329712 @default.
• W2103127735 hasRelatedWork W3038392370 @default.
• W2103127735 hasRelatedWork W3092437888 @default.
• W2103127735 hasRelatedWork W3154231528 @default.
• W2103127735 hasRelatedWork W3162666314 @default.
• W2103127735 hasVolume "8" @default.
• W2103127735 isParatext "false" @default.
• W2103127735 isRetracted "false" @default.
• W2103127735 magId "2103127735" @default.

• next