FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103129051> ?p ?o ?g. }

• W2103129051 abstract "Bone marrow derived progenitor cells participate in the repair of injured vessels. The lungs of individuals with emphysema have reduced alveolar capillary density and increased endothelial apoptosis. We hypothesized that circulating levels of endothelial and hematopoietic progenitor cells would be reduced in this group of patients.The goal of this study was to measure circulating levels of endothelial progenitor cells (EPCs) and hematopoietic progenitor cells (HPCs) in subjects with COPD and to determine if progenitor levels correlated with disease severity and the presence of emphysema.Peripheral blood mononuclear cells were isolated from 61 patients with COPD and 32 control subjects. Levels of EPCs (CD45(dim) CD34+) and HPCs (CD45(+) CD34(+) VEGF-R2(+)) were quantified using multi-parameter flow cytometry. Progenitor cell function was assessed using cell culture assays. All subjects were evaluated with spirometry and CT scanning.HPC levels were reduced in subjects with COPD compared to controls, whereas circulating EPC levels were similar between the two groups. HPC levels correlated with severity of obstruction and were lowest in subjects with severe emphysema. These associations remained after correction for factors known to affect progenitor cell levels including age, smoking status, the use of statin medications and the presence of coronary artery disease. The ability of mononuclear cells to form endothelial cell colony forming units (EC-CFU) was also reduced in subjects with COPD.HPC levels are reduced in subjects with COPD and correlate with emphysema phenotype and severity of obstruction. Reduction of HPCs may disrupt maintenance of the capillary endothelium, thereby contributing to the pathogenesis of COPD." @default.
• W2103129051 created "2016-06-24" @default.
• W2103129051 creator A5011108714 @default.
• W2103129051 creator A5017665414 @default.
• W2103129051 creator A5026130022 @default.
• W2103129051 creator A5026436514 @default.
• W2103129051 creator A5030906578 @default.
• W2103129051 creator A5052265989 @default.
• W2103129051 creator A5072916542 @default.
• W2103129051 creator A5074044567 @default.
• W2103129051 creator A5091532406 @default.
• W2103129051 date "2013-11-01" @default.
• W2103129051 modified "2023-09-24" @default.
• W2103129051 title "Circulating Hematopoietic Progenitor Cells are Decreased in COPD" @default.
• W2103129051 cites W116758555 @default.
• W2103129051 cites W1502896205 @default.
• W2103129051 cites W1671780354 @default.
• W2103129051 cites W1744833241 @default.
• W2103129051 cites W1870141733 @default.
• W2103129051 cites W1966685218 @default.
• W2103129051 cites W197648304 @default.
• W2103129051 cites W1978541986 @default.
• W2103129051 cites W1978834280 @default.
• W2103129051 cites W1979485167 @default.
• W2103129051 cites W1983979356 @default.
• W2103129051 cites W1986991023 @default.
• W2103129051 cites W1992940048 @default.
• W2103129051 cites W1999341915 @default.
• W2103129051 cites W2000292756 @default.
• W2103129051 cites W2004456466 @default.
• W2103129051 cites W2004907588 @default.
• W2103129051 cites W2004918005 @default.
• W2103129051 cites W2008062232 @default.
• W2103129051 cites W2011849709 @default.
• W2103129051 cites W2013489935 @default.
• W2103129051 cites W2017422879 @default.
• W2103129051 cites W2020707691 @default.
• W2103129051 cites W2025455693 @default.
• W2103129051 cites W2027222801 @default.
• W2103129051 cites W2030563465 @default.
• W2103129051 cites W2031280595 @default.
• W2103129051 cites W2035982551 @default.
• W2103129051 cites W2039673322 @default.
• W2103129051 cites W2042116568 @default.
• W2103129051 cites W2045765413 @default.
• W2103129051 cites W2046095585 @default.
• W2103129051 cites W2049180635 @default.
• W2103129051 cites W2052488548 @default.
• W2103129051 cites W2054084651 @default.
• W2103129051 cites W2066972199 @default.
• W2103129051 cites W2078924761 @default.
• W2103129051 cites W2082907106 @default.
• W2103129051 cites W2084397540 @default.
• W2103129051 cites W2085350659 @default.
• W2103129051 cites W2085390558 @default.
• W2103129051 cites W2090134402 @default.
• W2103129051 cites W2093664986 @default.
• W2103129051 cites W2096496561 @default.
• W2103129051 cites W2096773218 @default.
• W2103129051 cites W2104168490 @default.
• W2103129051 cites W2106629880 @default.
• W2103129051 cites W2110146694 @default.
• W2103129051 cites W2115830594 @default.
• W2103129051 cites W2116685107 @default.
• W2103129051 cites W2118749829 @default.
• W2103129051 cites W2119910176 @default.
• W2103129051 cites W2120379510 @default.
• W2103129051 cites W2120446028 @default.
• W2103129051 cites W2124631075 @default.
• W2103129051 cites W2127872440 @default.
• W2103129051 cites W2134654140 @default.
• W2103129051 cites W2138145190 @default.
• W2103129051 cites W2145524503 @default.
• W2103129051 cites W2149998982 @default.
• W2103129051 cites W2156849556 @default.
• W2103129051 cites W2157844015 @default.
• W2103129051 cites W2159241513 @default.
• W2103129051 cites W2161041506 @default.
• W2103129051 cites W2166406579 @default.
• W2103129051 cites W2169862468 @default.
• W2103129051 cites W2171650049 @default.
• W2103129051 cites W2319554819 @default.
• W2103129051 cites W4211263216 @default.
• W2103129051 cites W4236554944 @default.
• W2103129051 cites W88241752 @default.
• W2103129051 doi "https://doi.org/10.3109/15412555.2013.841668" @default.
• W2103129051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4112029" @default.
• W2103129051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24182349" @default.
• W2103129051 hasPublicationYear "2013" @default.
• W2103129051 type Work @default.
• W2103129051 sameAs 2103129051 @default.
• W2103129051 citedByCount "12" @default.
• W2103129051 countsByYear W21031290512016 @default.
• W2103129051 countsByYear W21031290512017 @default.
• W2103129051 countsByYear W21031290512018 @default.
• W2103129051 countsByYear W21031290512019 @default.
• W2103129051 crossrefType "journal-article" @default.
• W2103129051 hasAuthorship W2103129051A5011108714 @default.
• W2103129051 hasAuthorship W2103129051A5017665414 @default.
• W2103129051 hasAuthorship W2103129051A5026130022 @default.

• next