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- W2103129136 abstract "The murine scid mutation affects both V(D)J recombination and DNA repair. This mutation has been mapped to the gene encoding the catalytic subunit of the DNA-dependent protein kinase (DNA-PK), which is activated by DNA damage in normal cells. In scid mice, antigen receptor gene rearrangements are initiated normally, but impaired joining of coding ends prevents assembly of functional receptor genes, resulting in arrest of B- and T-cell development. Others have shown that exposure of scid mice to genotoxic agents such as gamma-irradiation rescues rearrangement at the T-cell receptor (TCR) beta locus and promotes thymocyte development. Here we demonstrate that irradiation rescues rearrangements at multiple TCR loci, suggesting a general effect on the recombination mechanism. Furthermore, our data show that p53 is required for irradiation-mediated rescue of both thymocyte development and V(D)J recombination. We also find that thymocyte proliferation and differentiation in the absence of DNA damage do not require p53 and are not sufficient to rescue V(D)J recombination. These results suggest that exposure to ionizing radiation facilitates a partial bypass of the scid defect, perhaps by inducing p53-dependent DNA damage response pathways." @default.
- W2103129136 created "2016-06-24" @default.
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- W2103129136 creator A5080482111 @default.
- W2103129136 creator A5087693607 @default.
- W2103129136 date "1996-03-01" @default.
- W2103129136 modified "2023-10-18" @default.
- W2103129136 title "p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes." @default.
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- W2103129136 doi "https://doi.org/10.1101/gad.10.5.553" @default.
- W2103129136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8598286" @default.
- W2103129136 hasPublicationYear "1996" @default.
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