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- W2103133071 abstract "Adrenal aldosterone production is regulated by physiological agonists at the level of early and late rate-limiting steps. Numerous studies have focused on the role of lipoproteins including high-density lipoprotein (HDL) as cholesterol providers in this process; however, recent research suggests that HDL can also act as a signaling molecule. Herein, we used the human H295R adrenocortical cell model to study the effects of HDL on adrenal aldosterone production and CYP11B2 expression. HDL, especially HDL2, stimulated aldosterone synthesis by increasing expression of CYP11B2. HDL treatment increased CYP11B2 mRNA in both a concentration- and time-dependent manner, with a maximal 19-fold increase (24 h, 250 μg/ml of HDL). Effects of HDL on CYP11B2 were not additive with natural agonists including angiotensin II or K+. HDL effects were likely mediated by a calcium signaling cascade, because a calcium channel blocker and a calmodulin kinase inhibitor abolished the CYP11B2-stimulating effects. Of the two subfractions of HDL, HDL2 was more potent than HDL3 in stimulating aldosterone and CYP11B2. Further studies are needed to identify the active components of HDL, which regulate aldosterone production." @default.
- W2103133071 created "2016-06-24" @default.
- W2103133071 creator A5003985413 @default.
- W2103133071 creator A5011099647 @default.
- W2103133071 creator A5028525455 @default.
- W2103133071 creator A5051555869 @default.
- W2103133071 creator A5053414120 @default.
- W2103133071 creator A5054457403 @default.
- W2103133071 creator A5059518260 @default.
- W2103133071 creator A5085226848 @default.
- W2103133071 date "2011-03-01" @default.
- W2103133071 modified "2023-10-15" @default.
- W2103133071 title "Aldosterone Production in Human Adrenocortical Cells Is Stimulated by High-Density Lipoprotein 2 (HDL2) through Increased Expression of Aldosterone Synthase (CYP11B2)" @default.
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