Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103135812> ?p ?o ?g. }
- W2103135812 endingPage "783" @default.
- W2103135812 startingPage "775" @default.
- W2103135812 abstract "The transcription factor Kruppel-like factor 2 (KLF2) was proposed to regulate genes involved in cell cycle entry and T cell trafficking; however, the physiological role of its expression in postactivated T cells is not well defined. Previous studies suggested that the cytokines IL-2 and IL-15 differentially regulate KLF2 re-expression in postactivation T cells and that these cytokines also influence effector versus memory T cell differentiation. Using conditional and inducible KLF2-knockout model systems, we tested the specific role of KLF2 expression in activated CD8(+) T cells cultured with these cytokines. KLF2 was required for effective transcription of sphingosine-1-phosphate receptor-1 (S1P(1)) and CD62L in postactivation T cells. However, although different cytokines dramatically altered the expression of cell-cycle-related genes, endogenous KLF2 had a minimal impact. Correspondingly, KLF2-deficient T cells showed dysregulated trafficking but not altered proliferative characteristics following in vivo responses to Ag. Thus, our data help to define KLF2-dependent and -independent aspects of activated CD8(+) T cell differentiation and argue against a physiological role in cell cycle regulation." @default.
- W2103135812 created "2016-06-24" @default.
- W2103135812 creator A5012285098 @default.
- W2103135812 creator A5014049435 @default.
- W2103135812 creator A5016217664 @default.
- W2103135812 creator A5024292230 @default.
- W2103135812 creator A5025915070 @default.
- W2103135812 creator A5048440698 @default.
- W2103135812 creator A5060316498 @default.
- W2103135812 date "2011-01-15" @default.
- W2103135812 modified "2023-09-25" @default.
- W2103135812 title "Kruppel-Like Factor 2 Is Required for Trafficking but Not Quiescence in Postactivated T Cells" @default.
- W2103135812 cites W1502597889 @default.
- W2103135812 cites W1528255432 @default.
- W2103135812 cites W1583135062 @default.
- W2103135812 cites W1867300250 @default.
- W2103135812 cites W1874259828 @default.
- W2103135812 cites W1966125710 @default.
- W2103135812 cites W1966427699 @default.
- W2103135812 cites W1968829231 @default.
- W2103135812 cites W1969954098 @default.
- W2103135812 cites W1970290521 @default.
- W2103135812 cites W1973427845 @default.
- W2103135812 cites W1975627280 @default.
- W2103135812 cites W1976062745 @default.
- W2103135812 cites W1976505472 @default.
- W2103135812 cites W1981721183 @default.
- W2103135812 cites W1995547197 @default.
- W2103135812 cites W1998405797 @default.
- W2103135812 cites W2002549598 @default.
- W2103135812 cites W2004181770 @default.
- W2103135812 cites W2004496629 @default.
- W2103135812 cites W2004603629 @default.
- W2103135812 cites W2004880863 @default.
- W2103135812 cites W2007672220 @default.
- W2103135812 cites W2011232667 @default.
- W2103135812 cites W2018735186 @default.
- W2103135812 cites W2019265636 @default.
- W2103135812 cites W2026243283 @default.
- W2103135812 cites W2036455976 @default.
- W2103135812 cites W2050514979 @default.
- W2103135812 cites W2053186332 @default.
- W2103135812 cites W2057781689 @default.
- W2103135812 cites W2070570719 @default.
- W2103135812 cites W2077916154 @default.
- W2103135812 cites W2094927488 @default.
- W2103135812 cites W2101099764 @default.
- W2103135812 cites W2112552541 @default.
- W2103135812 cites W2115352538 @default.
- W2103135812 cites W2120177140 @default.
- W2103135812 cites W2120481949 @default.
- W2103135812 cites W2126158890 @default.
- W2103135812 cites W2129103503 @default.
- W2103135812 cites W2133060333 @default.
- W2103135812 cites W2136358628 @default.
- W2103135812 cites W2142621481 @default.
- W2103135812 cites W2160863389 @default.
- W2103135812 cites W2161838780 @default.
- W2103135812 cites W2169495354 @default.
- W2103135812 cites W35999594 @default.
- W2103135812 cites W60142654 @default.
- W2103135812 doi "https://doi.org/10.4049/jimmunol.1000094" @default.
- W2103135812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3017213" @default.
- W2103135812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21160050" @default.
- W2103135812 hasPublicationYear "2011" @default.
- W2103135812 type Work @default.
- W2103135812 sameAs 2103135812 @default.
- W2103135812 citedByCount "49" @default.
- W2103135812 countsByYear W21031358122012 @default.
- W2103135812 countsByYear W21031358122013 @default.
- W2103135812 countsByYear W21031358122014 @default.
- W2103135812 countsByYear W21031358122015 @default.
- W2103135812 countsByYear W21031358122016 @default.
- W2103135812 countsByYear W21031358122017 @default.
- W2103135812 countsByYear W21031358122018 @default.
- W2103135812 countsByYear W21031358122019 @default.
- W2103135812 countsByYear W21031358122020 @default.
- W2103135812 countsByYear W21031358122021 @default.
- W2103135812 countsByYear W21031358122022 @default.
- W2103135812 countsByYear W21031358122023 @default.
- W2103135812 crossrefType "journal-article" @default.
- W2103135812 hasAuthorship W2103135812A5012285098 @default.
- W2103135812 hasAuthorship W2103135812A5014049435 @default.
- W2103135812 hasAuthorship W2103135812A5016217664 @default.
- W2103135812 hasAuthorship W2103135812A5024292230 @default.
- W2103135812 hasAuthorship W2103135812A5025915070 @default.
- W2103135812 hasAuthorship W2103135812A5048440698 @default.
- W2103135812 hasAuthorship W2103135812A5060316498 @default.
- W2103135812 hasBestOaLocation W21031358121 @default.
- W2103135812 hasConcept C104317684 @default.
- W2103135812 hasConcept C154317977 @default.
- W2103135812 hasConcept C167672396 @default.
- W2103135812 hasConcept C202751555 @default.
- W2103135812 hasConcept C203014093 @default.
- W2103135812 hasConcept C2776090121 @default.
- W2103135812 hasConcept C2777350992 @default.
- W2103135812 hasConcept C54355233 @default.
- W2103135812 hasConcept C86339819 @default.