FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103136574> ?p ?o ?g. }

• W2103136574 endingPage "645" @default.
• W2103136574 startingPage "629" @default.
• W2103136574 abstract "Cyclooxygenase-2 selective inhibitors (COXIBs) were developed with the prime object of minimizing gastrointestinal adverse effects, which are seen with the use of traditional nonsteroidal anti-inflammatory drugs (NSAIDs). Their long-term use is limited by the development of hypertension, edema, and congestive heart failure in a significant proportion of patients. NSAIDs block the activity of both COX isozymes, COX-1 and COX-2, which mediate the enzymatic conversion of arachidonate to prostaglandin H 2 (PGH 2 ) and other prostaglandin (PG) metabolites. It is well established that the cardiovascular profile of COX-2 inhibitors can be accounted for by inhibition of COX-dependent PG synthesis. Following the COX-mediated synthesis of PGH 2 from arachidonate, PGH 2 is metabolized to one of at least five bioactive PGs, including PGE 2 , PGI 2 , PGF 2 , PGD 2 , or thromboxane A 2 (TXA 2 ). These prostanoids have pleiotropic cardiovascular effects, altering platelet function and renal function, and they are acting either as vasodilators or vasoconstrictors. Although COX-1 and COX-2 exhibit similar biochemical activity in converting arachidonate to PGH 2 in vitro , the ultimate prostanoids they produce in vivo may be different due to differential regulation of COX-1 and COX-2, tissue distribution, and availability of the prostanoid synthases. PGs have been established as being critically involved in mitigating hypertension, helping to maintain medullary blood flow (MBF), promoting urinary salt excretion, and preserving the normal homeostasis of thrombosis, and the researchers found that the use of COX-2 inhibitors caused many serious complications in altering the normal body homeostasis. The purpose of the present research is to explain briefly the side effects of COX-2 inhibitors on the renal and cardiovascular system." @default.
• W2103136574 created "2016-06-24" @default.
• W2103136574 creator A5061385966 @default.
• W2103136574 creator A5063435871 @default.
• W2103136574 date "2005-01-01" @default.
• W2103136574 modified "2023-10-15" @default.
• W2103136574 title "Adverse Effects of COX-2 Inhibitors" @default.
• W2103136574 cites W100864779 @default.
• W2103136574 cites W1877100510 @default.
• W2103136574 cites W1986160028 @default.
• W2103136574 cites W2001162433 @default.
• W2103136574 cites W2002178040 @default.
• W2103136574 cites W2004827058 @default.
• W2103136574 cites W2010733654 @default.
• W2103136574 cites W2013855955 @default.
• W2103136574 cites W2018405069 @default.
• W2103136574 cites W2023085374 @default.
• W2103136574 cites W2023989156 @default.
• W2103136574 cites W2027645788 @default.
• W2103136574 cites W2036805823 @default.
• W2103136574 cites W2051249814 @default.
• W2103136574 cites W2052161927 @default.
• W2103136574 cites W2063841251 @default.
• W2103136574 cites W2086552393 @default.
• W2103136574 cites W2135085072 @default.
• W2103136574 cites W2141200506 @default.
• W2103136574 cites W2148744880 @default.
• W2103136574 cites W2158968701 @default.
• W2103136574 cites W2160684878 @default.
• W2103136574 cites W2167321599 @default.
• W2103136574 cites W2169213117 @default.
• W2103136574 cites W78745344 @default.
• W2103136574 cites W97893626 @default.
• W2103136574 cites W1995043560 @default.
• W2103136574 cites W2516307768 @default.
• W2103136574 doi "https://doi.org/10.1100/tsw.2005.82" @default.
• W2103136574 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5936602" @default.
• W2103136574 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16113940" @default.
• W2103136574 hasPublicationYear "2005" @default.
• W2103136574 type Work @default.
• W2103136574 sameAs 2103136574 @default.
• W2103136574 citedByCount "29" @default.
• W2103136574 countsByYear W21031365742012 @default.
• W2103136574 countsByYear W21031365742013 @default.
• W2103136574 countsByYear W21031365742014 @default.
• W2103136574 countsByYear W21031365742015 @default.
• W2103136574 countsByYear W21031365742016 @default.
• W2103136574 countsByYear W21031365742017 @default.
• W2103136574 countsByYear W21031365742018 @default.
• W2103136574 countsByYear W21031365742019 @default.
• W2103136574 countsByYear W21031365742021 @default.
• W2103136574 countsByYear W21031365742022 @default.
• W2103136574 countsByYear W21031365742023 @default.
• W2103136574 crossrefType "journal-article" @default.
• W2103136574 hasAuthorship W2103136574A5061385966 @default.
• W2103136574 hasAuthorship W2103136574A5063435871 @default.
• W2103136574 hasBestOaLocation W21031365741 @default.
• W2103136574 hasConcept C126322002 @default.
• W2103136574 hasConcept C150903083 @default.
• W2103136574 hasConcept C181199279 @default.
• W2103136574 hasConcept C185592680 @default.
• W2103136574 hasConcept C207001950 @default.
• W2103136574 hasConcept C2776785769 @default.
• W2103136574 hasConcept C2778266237 @default.
• W2103136574 hasConcept C2779689624 @default.
• W2103136574 hasConcept C2780664492 @default.
• W2103136574 hasConcept C2780886150 @default.
• W2103136574 hasConcept C2781024287 @default.
• W2103136574 hasConcept C55493867 @default.
• W2103136574 hasConcept C71924100 @default.
• W2103136574 hasConcept C86803240 @default.
• W2103136574 hasConcept C89560881 @default.
• W2103136574 hasConcept C98274493 @default.
• W2103136574 hasConceptScore W2103136574C126322002 @default.
• W2103136574 hasConceptScore W2103136574C150903083 @default.
• W2103136574 hasConceptScore W2103136574C181199279 @default.
• W2103136574 hasConceptScore W2103136574C185592680 @default.
• W2103136574 hasConceptScore W2103136574C207001950 @default.
• W2103136574 hasConceptScore W2103136574C2776785769 @default.
• W2103136574 hasConceptScore W2103136574C2778266237 @default.
• W2103136574 hasConceptScore W2103136574C2779689624 @default.
• W2103136574 hasConceptScore W2103136574C2780664492 @default.
• W2103136574 hasConceptScore W2103136574C2780886150 @default.
• W2103136574 hasConceptScore W2103136574C2781024287 @default.
• W2103136574 hasConceptScore W2103136574C55493867 @default.
• W2103136574 hasConceptScore W2103136574C71924100 @default.
• W2103136574 hasConceptScore W2103136574C86803240 @default.
• W2103136574 hasConceptScore W2103136574C89560881 @default.
• W2103136574 hasConceptScore W2103136574C98274493 @default.
• W2103136574 hasLocation W21031365741 @default.
• W2103136574 hasLocation W21031365742 @default.
• W2103136574 hasLocation W21031365743 @default.
• W2103136574 hasLocation W21031365744 @default.
• W2103136574 hasOpenAccess W2103136574 @default.
• W2103136574 hasPrimaryLocation W21031365741 @default.
• W2103136574 hasRelatedWork W1216252767 @default.
• W2103136574 hasRelatedWork W1989085117 @default.
• W2103136574 hasRelatedWork W1996409233 @default.

• next