FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103136643> ?p ?o ?g. }

• W2103136643 endingPage "366" @default.
• W2103136643 startingPage "360" @default.
• W2103136643 abstract "ABSTRACT Azithromycin (AZI) is an azalide antibiotic with antimalarial activity that is considered safe in pregnancy. To assess its pharmacokinetic properties when administered as intermittent preventive treatment in pregnancy (IPTp), two 2-g doses were given 24 h apart to 31 pregnant and 29 age-matched nonpregnant Papua New Guinean women. All subjects also received single-dose sulfadoxine-pyrimethamine (SP) (1,500 mg or 75 mg) or chloroquine (450-mg base daily for 3 days). Blood samples were taken at 0, 1, 2, 3, 6, 12, 24, 32, 40, 48, and 72 h and on days 4, 5, 7, 10, and 14 for AZI assay by ultra-high-performance liquid chromatography-tandem mass spectrometry. The treatments were well tolerated. Using population pharmacokinetic modeling, a three-compartment model with zero-order followed by first-order absorption and no lag time provided the best fit. The areas under the plasma concentration-time curve (AUC 0-∞ ) (28.7 and 31.8 mg·h liter −1 for pregnant and nonpregnant subjects, respectively) were consistent with the results of previous studies, but the estimated terminal elimination half-lives (78 and 77 h, respectively) were generally longer. The only significant relationship for a range of potential covariates, including malarial parasitemia, was with pregnancy, which accounted for an 86% increase in the volume of distribution of the central compartment relative to bioavailability without a significant change in the AUC 0-∞ . These data suggest that AZI can be combined with compounds with longer half-lives, such as SP, in combination IPTp without the need for dose adjustment." @default.
• W2103136643 created "2016-06-24" @default.
• W2103136643 creator A5004026303 @default.
• W2103136643 creator A5004820565 @default.
• W2103136643 creator A5006561542 @default.
• W2103136643 creator A5031856201 @default.
• W2103136643 creator A5035551748 @default.
• W2103136643 creator A5043426673 @default.
• W2103136643 creator A5046604150 @default.
• W2103136643 creator A5049265849 @default.
• W2103136643 creator A5051742968 @default.
• W2103136643 creator A5064315103 @default.
• W2103136643 creator A5082061848 @default.
• W2103136643 creator A5083478451 @default.
• W2103136643 creator A5084635606 @default.
• W2103136643 creator A5086085171 @default.
• W2103136643 date "2010-01-01" @default.
• W2103136643 modified "2023-09-25" @default.
• W2103136643 title "Pharmacokinetic Properties of Azithromycin in Pregnancy" @default.
• W2103136643 cites W1840586683 @default.
• W2103136643 cites W1964763802 @default.
• W2103136643 cites W1967127038 @default.
• W2103136643 cites W1969660680 @default.
• W2103136643 cites W1969763842 @default.
• W2103136643 cites W1974148310 @default.
• W2103136643 cites W1977607663 @default.
• W2103136643 cites W1991206160 @default.
• W2103136643 cites W1996122690 @default.
• W2103136643 cites W1996184528 @default.
• W2103136643 cites W1997496598 @default.
• W2103136643 cites W1998342146 @default.
• W2103136643 cites W2006148788 @default.
• W2103136643 cites W2007760422 @default.
• W2103136643 cites W2010568902 @default.
• W2103136643 cites W2013104419 @default.
• W2103136643 cites W2017261836 @default.
• W2103136643 cites W2026821857 @default.
• W2103136643 cites W2066464642 @default.
• W2103136643 cites W2080803945 @default.
• W2103136643 cites W2092394044 @default.
• W2103136643 cites W2096994469 @default.
• W2103136643 cites W2100119109 @default.
• W2103136643 cites W2111033886 @default.
• W2103136643 cites W2111386567 @default.
• W2103136643 cites W2120416054 @default.
• W2103136643 cites W2127587232 @default.
• W2103136643 cites W2129127053 @default.
• W2103136643 cites W2143648287 @default.
• W2103136643 cites W2144175940 @default.
• W2103136643 cites W2144374479 @default.
• W2103136643 cites W2145891230 @default.
• W2103136643 cites W2146569193 @default.
• W2103136643 cites W2159601567 @default.
• W2103136643 cites W2171579740 @default.
• W2103136643 cites W2183005773 @default.
• W2103136643 cites W2185127450 @default.
• W2103136643 doi "https://doi.org/10.1128/aac.00771-09" @default.
• W2103136643 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2798488" @default.
• W2103136643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19858250" @default.
• W2103136643 hasPublicationYear "2010" @default.
• W2103136643 type Work @default.
• W2103136643 sameAs 2103136643 @default.
• W2103136643 citedByCount "44" @default.
• W2103136643 countsByYear W21031366432012 @default.
• W2103136643 countsByYear W21031366432013 @default.
• W2103136643 countsByYear W21031366432014 @default.
• W2103136643 countsByYear W21031366432015 @default.
• W2103136643 countsByYear W21031366432016 @default.
• W2103136643 countsByYear W21031366432017 @default.
• W2103136643 countsByYear W21031366432018 @default.
• W2103136643 countsByYear W21031366432019 @default.
• W2103136643 countsByYear W21031366432020 @default.
• W2103136643 countsByYear W21031366432021 @default.
• W2103136643 countsByYear W21031366432022 @default.
• W2103136643 countsByYear W21031366432023 @default.
• W2103136643 crossrefType "journal-article" @default.
• W2103136643 hasAuthorship W2103136643A5004026303 @default.
• W2103136643 hasAuthorship W2103136643A5004820565 @default.
• W2103136643 hasAuthorship W2103136643A5006561542 @default.
• W2103136643 hasAuthorship W2103136643A5031856201 @default.
• W2103136643 hasAuthorship W2103136643A5035551748 @default.
• W2103136643 hasAuthorship W2103136643A5043426673 @default.
• W2103136643 hasAuthorship W2103136643A5046604150 @default.
• W2103136643 hasAuthorship W2103136643A5049265849 @default.
• W2103136643 hasAuthorship W2103136643A5051742968 @default.
• W2103136643 hasAuthorship W2103136643A5064315103 @default.
• W2103136643 hasAuthorship W2103136643A5082061848 @default.
• W2103136643 hasAuthorship W2103136643A5083478451 @default.
• W2103136643 hasAuthorship W2103136643A5084635606 @default.
• W2103136643 hasAuthorship W2103136643A5086085171 @default.
• W2103136643 hasBestOaLocation W21031366432 @default.
• W2103136643 hasConcept C112705442 @default.
• W2103136643 hasConcept C126322002 @default.
• W2103136643 hasConcept C139254425 @default.
• W2103136643 hasConcept C181389837 @default.
• W2103136643 hasConcept C203014093 @default.
• W2103136643 hasConcept C2777035104 @default.
• W2103136643 hasConcept C2777425658 @default.

• next