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• W2103136667 startingPage "e0141351" @default.
• W2103136667 abstract "Allele-specific gene expression associated with genetic variation in regulatory regions can play an important role in the development of complex traits. We hypothesized that polymorphisms in microRNA (miRNA) response elements (MRE-SNPs) that either disrupt a miRNA binding site or create a new miRNA binding site can affect the allele-specific expression of target genes. By integrating public expression quantitative trait locus (eQTL) data, miRNA binding site predictions, small RNA sequencing, and Argonaute crosslinking immunoprecipitation (AGO-CLIP) datasets, we identified genetic variants that can affect gene expression by modulating miRNA binding efficiency. We also identified MRE-SNPs located in regions associated with complex traits, indicating possible causative mechanisms associated with these loci. The results of this study expand the current understanding of gene expression regulation and help to interpret the mechanisms underlying eQTL effects." @default.
• W2103136667 created "2016-06-24" @default.
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• W2103136667 date "2015-10-23" @default.
• W2103136667 modified "2023-10-09" @default.
• W2103136667 title "Altered Gene Expression Associated with microRNA Binding Site Polymorphisms" @default.
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• W2103136667 doi "https://doi.org/10.1371/journal.pone.0141351" @default.
• W2103136667 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4619707" @default.
• W2103136667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26496489" @default.
• W2103136667 hasPublicationYear "2015" @default.
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