Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103143422> ?p ?o ?g. }
- W2103143422 endingPage "e27" @default.
- W2103143422 startingPage "e27" @default.
- W2103143422 abstract "Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF moieties to the cytosol. Recently, the low-density lipoprotein receptor-related protein LRP6 has been reported to mediate internalization and lethality of AnTx. Based on its similarity to LRP6, we hypothesized that LRP5 may also play a role in cellular uptake of AnTx. We assayed PA-dependent uptake of anthrax LF or a cytotoxic LF fusion protein (FP59) in cells and mice harboring targeted deletions of Lrp5 or Lrp6. Unexpectedly, we observed that uptake was unaltered in the presence or absence of either Lrp5 or Lrp6 expression. Moreover, we observed efficient PA-mediated uptake into anthrax toxin receptor (ANTXR)-deficient Chinese hamster ovary cells (PR230) that had been stably engineered to express either human ANTXR1 or human ANTXR2 in the presence or absence of siRNA specific for LRP5 or LRP6. Our results demonstrate that neither LRP5 nor LRP6 is necessary for PA-mediated internalization or lethality of anthrax lethal toxin." @default.
- W2103143422 created "2016-06-24" @default.
- W2103143422 creator A5018051847 @default.
- W2103143422 creator A5021839708 @default.
- W2103143422 creator A5031101248 @default.
- W2103143422 creator A5033790013 @default.
- W2103143422 creator A5033838605 @default.
- W2103143422 creator A5039167731 @default.
- W2103143422 creator A5078641175 @default.
- W2103143422 creator A5037451480 @default.
- W2103143422 date "2007-03-02" @default.
- W2103143422 modified "2023-10-18" @default.
- W2103143422 title "LRP5 and LRP6 Are Not Required for Protective Antigen–Mediated Internalization or Lethality of Anthrax Lethal Toxin" @default.
- W2103143422 cites W1504655784 @default.
- W2103143422 cites W1536607091 @default.
- W2103143422 cites W1546423706 @default.
- W2103143422 cites W1552850613 @default.
- W2103143422 cites W1610696702 @default.
- W2103143422 cites W1611720630 @default.
- W2103143422 cites W1635607892 @default.
- W2103143422 cites W1692891995 @default.
- W2103143422 cites W1749453950 @default.
- W2103143422 cites W1837364493 @default.
- W2103143422 cites W1926803865 @default.
- W2103143422 cites W1974516704 @default.
- W2103143422 cites W1974917488 @default.
- W2103143422 cites W1975648878 @default.
- W2103143422 cites W1979095884 @default.
- W2103143422 cites W1980066894 @default.
- W2103143422 cites W1980847339 @default.
- W2103143422 cites W1982959059 @default.
- W2103143422 cites W1983025057 @default.
- W2103143422 cites W1995910871 @default.
- W2103143422 cites W2002073678 @default.
- W2103143422 cites W2002272803 @default.
- W2103143422 cites W2004693684 @default.
- W2103143422 cites W2012529940 @default.
- W2103143422 cites W2013087654 @default.
- W2103143422 cites W2014719030 @default.
- W2103143422 cites W2015148410 @default.
- W2103143422 cites W2015602170 @default.
- W2103143422 cites W2029456301 @default.
- W2103143422 cites W2037132744 @default.
- W2103143422 cites W2044103113 @default.
- W2103143422 cites W2056301653 @default.
- W2103143422 cites W2066464418 @default.
- W2103143422 cites W2070374560 @default.
- W2103143422 cites W2078241837 @default.
- W2103143422 cites W2079148785 @default.
- W2103143422 cites W2083670089 @default.
- W2103143422 cites W2086694435 @default.
- W2103143422 cites W2101355256 @default.
- W2103143422 cites W2104916769 @default.
- W2103143422 cites W2108624125 @default.
- W2103143422 cites W2111113377 @default.
- W2103143422 cites W2116610925 @default.
- W2103143422 cites W2117013761 @default.
- W2103143422 cites W2119413986 @default.
- W2103143422 cites W2143792029 @default.
- W2103143422 cites W2163329733 @default.
- W2103143422 cites W2163457209 @default.
- W2103143422 cites W2328119231 @default.
- W2103143422 cites W2411942838 @default.
- W2103143422 cites W4232534952 @default.
- W2103143422 doi "https://doi.org/10.1371/journal.ppat.0030027" @default.
- W2103143422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1808072" @default.
- W2103143422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17335347" @default.
- W2103143422 hasPublicationYear "2007" @default.
- W2103143422 type Work @default.
- W2103143422 sameAs 2103143422 @default.
- W2103143422 citedByCount "38" @default.
- W2103143422 countsByYear W21031434222012 @default.
- W2103143422 countsByYear W21031434222013 @default.
- W2103143422 countsByYear W21031434222014 @default.
- W2103143422 countsByYear W21031434222015 @default.
- W2103143422 countsByYear W21031434222017 @default.
- W2103143422 crossrefType "journal-article" @default.
- W2103143422 hasAuthorship W2103143422A5018051847 @default.
- W2103143422 hasAuthorship W2103143422A5021839708 @default.
- W2103143422 hasAuthorship W2103143422A5031101248 @default.
- W2103143422 hasAuthorship W2103143422A5033790013 @default.
- W2103143422 hasAuthorship W2103143422A5033838605 @default.
- W2103143422 hasAuthorship W2103143422A5037451480 @default.
- W2103143422 hasAuthorship W2103143422A5039167731 @default.
- W2103143422 hasAuthorship W2103143422A5078641175 @default.
- W2103143422 hasBestOaLocation W21031434221 @default.
- W2103143422 hasConcept C104317684 @default.
- W2103143422 hasConcept C123894998 @default.
- W2103143422 hasConcept C139770010 @default.
- W2103143422 hasConcept C170493617 @default.
- W2103143422 hasConcept C175656101 @default.
- W2103143422 hasConcept C2780239966 @default.
- W2103143422 hasConcept C40767141 @default.
- W2103143422 hasConcept C41810244 @default.
- W2103143422 hasConcept C523546767 @default.
- W2103143422 hasConcept C54355233 @default.
- W2103143422 hasConcept C55493867 @default.
- W2103143422 hasConcept C86803240 @default.