FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103145251> ?p ?o ?g. }

• W2103145251 endingPage "45" @default.
• W2103145251 startingPage "37" @default.
• W2103145251 abstract "Patients with CKD display altered plasma amino acid profiles. This study estimated the association between the estimated GFR and urinary and plasma amino acid profiles in CKD patients.Urine and plasma samples were taken from 52 patients with different stages of CKD, and plasma samples only were taken from 25 patients on maintenance hemodialysis. Metabolic profiling was performed by liquid chromatography coupled with tandem mass spectrometry after phenylisothiocyanate derivatization.Most plasma amino acid concentrations were decreased in hemodialysis patients, whereas proline, citrulline, asparagine, asymmetric dimethylarginine, and hydroxykynurenine levels were increased (P<0.05). Both plasma levels and urinary excretion of citrulline were higher in the group of patients with advanced CKD (CKD stages 2 and 3 versus CKD stages 4 and 5; in plasma: 35.9±16.3 versus 61.8±23.6 µmol/L, P<0.01; in urine: 1.0±1.2 versus 7.1±14.3 µmol/mol creatinine, P<0.001). Plasma asymmetric dimethylarginine levels were higher in advanced CKD (CKD stages 2 and 3, 0.57±0.29; CKD stages 4 and 5, 1.02±0.48, P<0.001), whereas urinary excretion was lower (2.37±0.93 versus 1.51±1.43, P<0.001). Multivariate analyses adjusting on estimated GFR, serum albumin, proteinuria, and other covariates revealed associations between diabetes and plasma citrulline (P=0.02) and between serum sodium and plasma asymmetric dimethylarginine (P=0.03). Plasma tyrosine to phenylalanine and valine to glycine ratios were lower in advanced CKD stages (P<0.01).CKD patients have altered plasma and urinary amino acid profiles that are not corrected by dialysis. Depending on solutes, elevated plasma levels were associated with increased or decreased urinary excretion, depicting situations of uremic retention (asymmetric dimethylarginine) or systemic overproduction (citrulline). These results give some insight in the CKD-associated modifications of amino acid metabolism, which may help improve their handling." @default.
• W2103145251 created "2016-06-24" @default.
• W2103145251 creator A5003294082 @default.
• W2103145251 creator A5024880435 @default.
• W2103145251 creator A5036073309 @default.
• W2103145251 creator A5052560289 @default.
• W2103145251 creator A5061537791 @default.
• W2103145251 creator A5065664298 @default.
• W2103145251 creator A5078595079 @default.
• W2103145251 creator A5085892087 @default.
• W2103145251 creator A5090125794 @default.
• W2103145251 date "2013-11-14" @default.
• W2103145251 modified "2023-10-15" @default.
• W2103145251 title "Plasma and Urinary Amino Acid Metabolomic Profiling in Patients with Different Levels of Kidney Function" @default.
• W2103145251 cites W1835869439 @default.
• W2103145251 cites W1967321148 @default.
• W2103145251 cites W1968267475 @default.
• W2103145251 cites W1969275896 @default.
• W2103145251 cites W1971606140 @default.
• W2103145251 cites W1976713062 @default.
• W2103145251 cites W1987384005 @default.
• W2103145251 cites W1992101378 @default.
• W2103145251 cites W1997860322 @default.
• W2103145251 cites W2001003092 @default.
• W2103145251 cites W2035655266 @default.
• W2103145251 cites W2058901084 @default.
• W2103145251 cites W2067261577 @default.
• W2103145251 cites W2070869944 @default.
• W2103145251 cites W2078208948 @default.
• W2103145251 cites W2089159224 @default.
• W2103145251 cites W2101447446 @default.
• W2103145251 cites W2109207751 @default.
• W2103145251 cites W2111131756 @default.
• W2103145251 cites W2115001982 @default.
• W2103145251 cites W2117156673 @default.
• W2103145251 cites W2122231873 @default.
• W2103145251 cites W2134927762 @default.
• W2103145251 cites W2137274797 @default.
• W2103145251 cites W2141128375 @default.
• W2103145251 cites W2145073188 @default.
• W2103145251 cites W2156584371 @default.
• W2103145251 cites W2161974326 @default.
• W2103145251 cites W2491439618 @default.
• W2103145251 cites W4245090897 @default.
• W2103145251 cites W4255939540 @default.
• W2103145251 doi "https://doi.org/10.2215/cjn.06000613" @default.
• W2103145251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3878706" @default.
• W2103145251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24235289" @default.
• W2103145251 hasPublicationYear "2013" @default.
• W2103145251 type Work @default.
• W2103145251 sameAs 2103145251 @default.
• W2103145251 citedByCount "147" @default.
• W2103145251 countsByYear W21031452512014 @default.
• W2103145251 countsByYear W21031452512015 @default.
• W2103145251 countsByYear W21031452512016 @default.
• W2103145251 countsByYear W21031452512017 @default.
• W2103145251 countsByYear W21031452512018 @default.
• W2103145251 countsByYear W21031452512019 @default.
• W2103145251 countsByYear W21031452512020 @default.
• W2103145251 countsByYear W21031452512021 @default.
• W2103145251 countsByYear W21031452512022 @default.
• W2103145251 countsByYear W21031452512023 @default.
• W2103145251 crossrefType "journal-article" @default.
• W2103145251 hasAuthorship W2103145251A5003294082 @default.
• W2103145251 hasAuthorship W2103145251A5024880435 @default.
• W2103145251 hasAuthorship W2103145251A5036073309 @default.
• W2103145251 hasAuthorship W2103145251A5052560289 @default.
• W2103145251 hasAuthorship W2103145251A5061537791 @default.
• W2103145251 hasAuthorship W2103145251A5065664298 @default.
• W2103145251 hasAuthorship W2103145251A5078595079 @default.
• W2103145251 hasAuthorship W2103145251A5085892087 @default.
• W2103145251 hasAuthorship W2103145251A5090125794 @default.
• W2103145251 hasBestOaLocation W21031452511 @default.
• W2103145251 hasConcept C126322002 @default.
• W2103145251 hasConcept C134018914 @default.
• W2103145251 hasConcept C159641895 @default.
• W2103145251 hasConcept C185592680 @default.
• W2103145251 hasConcept C2777468819 @default.
• W2103145251 hasConcept C2777573094 @default.
• W2103145251 hasConcept C2778653478 @default.
• W2103145251 hasConcept C2779561371 @default.
• W2103145251 hasConcept C2779877776 @default.
• W2103145251 hasConcept C2780026642 @default.
• W2103145251 hasConcept C2780091579 @default.
• W2103145251 hasConcept C2780306776 @default.
• W2103145251 hasConcept C2780343553 @default.
• W2103145251 hasConcept C515207424 @default.
• W2103145251 hasConcept C55493867 @default.
• W2103145251 hasConcept C555293320 @default.
• W2103145251 hasConcept C71924100 @default.
• W2103145251 hasConcept C77411442 @default.
• W2103145251 hasConceptScore W2103145251C126322002 @default.
• W2103145251 hasConceptScore W2103145251C134018914 @default.
• W2103145251 hasConceptScore W2103145251C159641895 @default.
• W2103145251 hasConceptScore W2103145251C185592680 @default.
• W2103145251 hasConceptScore W2103145251C2777468819 @default.
• W2103145251 hasConceptScore W2103145251C2777573094 @default.
• W2103145251 hasConceptScore W2103145251C2778653478 @default.

• next