FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103149664> ?p ?o ?g. }

• W2103149664 endingPage "14286" @default.
• W2103149664 startingPage "14281" @default.
• W2103149664 abstract "To eliminate apicomplexan parasites, inhibitory compounds must cross host cell, parasitophorous vacuole, and parasite membranes and cyst walls, making delivery challenging. Here, we show that short oligomers of arginine enter Toxoplasma gondii tachyzoites and encysted bradyzoites. Triclosan, which inhibits enoyl-ACP reductase (ENR), conjugated to arginine oligomers enters extracellular tachyzoites, host cells, tachyzoites inside parasitophorous vacuoles within host cells, extracellular bradyzoites, and bradyzoites within cysts. We identify, clone, and sequence T. gondii enr and produce and characterize enzymatically active, recombinant ENR. This enzyme has the requisite amino acids to bind triclosan. Triclosan released after conjugation to octaarginine via a readily hydrolyzable ester linkage inhibits ENR activity, tachyzoites in vitro , and tachyzoites in mice. Delivery of an inhibitor to a microorganism via conjugation to octaarginine provides an approach to transporting antimicrobials and other small molecules to sequestered parasites, a model system to characterize transport across multiple membrane barriers and structures, a widely applicable paradigm for treatment of active and encysted apicomplexan and other infections, and a generic proof of principle for a mechanism of medicine delivery." @default.
• W2103149664 created "2016-06-24" @default.
• W2103149664 creator A5007640308 @default.
• W2103149664 creator A5008592082 @default.
• W2103149664 creator A5009008418 @default.
• W2103149664 creator A5009899105 @default.
• W2103149664 creator A5013134145 @default.
• W2103149664 creator A5029138719 @default.
• W2103149664 creator A5029325456 @default.
• W2103149664 creator A5040139721 @default.
• W2103149664 creator A5049114543 @default.
• W2103149664 creator A5058557105 @default.
• W2103149664 creator A5060002438 @default.
• W2103149664 creator A5069819355 @default.
• W2103149664 creator A5076400884 @default.
• W2103149664 creator A5091396761 @default.
• W2103149664 date "2003-11-17" @default.
• W2103149664 modified "2023-10-14" @default.
• W2103149664 title "Delivery of antimicrobials into parasites" @default.
• W2103149664 cites W1499640952 @default.
• W2103149664 cites W1590085201 @default.
• W2103149664 cites W1668167434 @default.
• W2103149664 cites W1937163697 @default.
• W2103149664 cites W1995734836 @default.
• W2103149664 cites W2004917621 @default.
• W2103149664 cites W2017136904 @default.
• W2103149664 cites W2049679577 @default.
• W2103149664 cites W2056252656 @default.
• W2103149664 cites W2079084833 @default.
• W2103149664 cites W2085345576 @default.
• W2103149664 cites W2094113765 @default.
• W2103149664 cites W2111994795 @default.
• W2103149664 cites W2123650819 @default.
• W2103149664 cites W2129095580 @default.
• W2103149664 cites W2146861732 @default.
• W2103149664 cites W2171091522 @default.
• W2103149664 doi "https://doi.org/10.1073/pnas.2436169100" @default.
• W2103149664 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/283583" @default.
• W2103149664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14623959" @default.
• W2103149664 hasPublicationYear "2003" @default.
• W2103149664 type Work @default.
• W2103149664 sameAs 2103149664 @default.
• W2103149664 citedByCount "65" @default.
• W2103149664 countsByYear W21031496642012 @default.
• W2103149664 countsByYear W21031496642013 @default.
• W2103149664 countsByYear W21031496642014 @default.
• W2103149664 countsByYear W21031496642015 @default.
• W2103149664 countsByYear W21031496642016 @default.
• W2103149664 countsByYear W21031496642017 @default.
• W2103149664 countsByYear W21031496642018 @default.
• W2103149664 countsByYear W21031496642020 @default.
• W2103149664 countsByYear W21031496642021 @default.
• W2103149664 countsByYear W21031496642022 @default.
• W2103149664 countsByYear W21031496642023 @default.
• W2103149664 crossrefType "journal-article" @default.
• W2103149664 hasAuthorship W2103149664A5007640308 @default.
• W2103149664 hasAuthorship W2103149664A5008592082 @default.
• W2103149664 hasAuthorship W2103149664A5009008418 @default.
• W2103149664 hasAuthorship W2103149664A5009899105 @default.
• W2103149664 hasAuthorship W2103149664A5013134145 @default.
• W2103149664 hasAuthorship W2103149664A5029138719 @default.
• W2103149664 hasAuthorship W2103149664A5029325456 @default.
• W2103149664 hasAuthorship W2103149664A5040139721 @default.
• W2103149664 hasAuthorship W2103149664A5049114543 @default.
• W2103149664 hasAuthorship W2103149664A5058557105 @default.
• W2103149664 hasAuthorship W2103149664A5060002438 @default.
• W2103149664 hasAuthorship W2103149664A5069819355 @default.
• W2103149664 hasAuthorship W2103149664A5076400884 @default.
• W2103149664 hasAuthorship W2103149664A5091396761 @default.
• W2103149664 hasBestOaLocation W21031496642 @default.
• W2103149664 hasConcept C102568950 @default.
• W2103149664 hasConcept C104317684 @default.
• W2103149664 hasConcept C142724271 @default.
• W2103149664 hasConcept C159654299 @default.
• W2103149664 hasConcept C185592680 @default.
• W2103149664 hasConcept C190062978 @default.
• W2103149664 hasConcept C203014093 @default.
• W2103149664 hasConcept C2777468819 @default.
• W2103149664 hasConcept C2778128430 @default.
• W2103149664 hasConcept C2781289450 @default.
• W2103149664 hasConcept C28406088 @default.
• W2103149664 hasConcept C40767141 @default.
• W2103149664 hasConcept C4937899 @default.
• W2103149664 hasConcept C515207424 @default.
• W2103149664 hasConcept C55493867 @default.
• W2103149664 hasConcept C71924100 @default.
• W2103149664 hasConcept C86803240 @default.
• W2103149664 hasConcept C89423630 @default.
• W2103149664 hasConcept C95444343 @default.
• W2103149664 hasConceptScore W2103149664C102568950 @default.
• W2103149664 hasConceptScore W2103149664C104317684 @default.
• W2103149664 hasConceptScore W2103149664C142724271 @default.
• W2103149664 hasConceptScore W2103149664C159654299 @default.
• W2103149664 hasConceptScore W2103149664C185592680 @default.
• W2103149664 hasConceptScore W2103149664C190062978 @default.
• W2103149664 hasConceptScore W2103149664C203014093 @default.
• W2103149664 hasConceptScore W2103149664C2777468819 @default.
• W2103149664 hasConceptScore W2103149664C2778128430 @default.

• next