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- W2103152778 abstract "Rationale: T cells play a critical role in the development of Saccharopolyspora rectivirgula-induced hypersensitivity pneumonitis (HP) but little is known about the role of IL-17A in this disease.Objectives: We examined the role of IL-17A in a murine model of S. rectivirgula antigen (SR-Ag)-induced HP.Methods: Experimental HP was induced by oropharyngeal instillation of SR-Ag in wild-type and IL-17 gene-deficient mice.Measurements and Main Results: SR-Ag–induced murine HP was characterized by increased transcript levels of IFN-γ and IL-12p35 compared with saline-treated control mice. Furthermore, mice with HP showed increased IL-17 in lung homogenates, bronchoalveolar lavage fluid, and ex-vivo lung cultures compared with control mice. Flow cytometric analysis of SR-Ag–challenged lungs revealed increased Th17 and CD11c+ cells. The role of IL-17 in SR-induced HP was examined in IL-17 deficient (IL17−/−) and in wild-type (IL-17+/+) mice immunodepleted of IL-17. Histological examination of IL17−/− mice challenged with SR-Ag revealed reduced inflammatory cell infiltration, decreased CD11c+ cells, and reduced levels of inflammatory mediators such as IL-12p70, CCL3, and CXCL9 compared with similarly treated IL17+/+ mice. Anti–IL-17 antibody treatment of IL-17+/+ mice with HP resulted in reduced inflammation and a lower percentage of CD11c+ cells compared with IgG-treated IL-17+/+ mice with HP.Conclusions: SR-Ag–induced IL-17 plays a pivotal role in the immunopathology of HP and targeting IL-17 is an attractive therapeutic option for this disease." @default.
- W2103152778 created "2016-06-24" @default.
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- W2103152778 date "2009-04-15" @default.
- W2103152778 modified "2023-09-27" @default.
- W2103152778 title "Interleukin-17–mediated Immunopathogenesis in Experimental Hypersensitivity Pneumonitis" @default.
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- W2103152778 doi "https://doi.org/10.1164/rccm.200811-1700oc" @default.
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