Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103155504> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2103155504 endingPage "1447" @default.
- W2103155504 startingPage "1444" @default.
- W2103155504 abstract "This study describes a novel method which could be developed into a test system of evaluating the efficacy of antileprosy drugs. The method estimates incorporation of [14C]acetate into lipids of Mycobacterium leprae maintained within the 33B Schwannoma cell line. Schwannoma cell-resident M. leprae cells incorporated significant levels of radiolabel within their lipids during 12 days of incubation in vitro. This incorporation was markedly reduced by 5 micrograms of rifampin per ml (decrease, 81.62%); this decrease was observed within 24 h of addition of the drug. Dapsone also reduced the radiolabel incorporation into the lipids, but to a lesser extent (decrease, 27.58%). This system was also able to differentiate between rifampin-sensitive and -resistant strains of mycobacteria. It is suggested that since the effect of bacteriostatic (dapsone) and bactericidal (rifampin) drugs could be detected by using this technique, it may prove useful in screening novel drugs acting against M. leprae." @default.
- W2103155504 created "2016-06-24" @default.
- W2103155504 creator A5015679073 @default.
- W2103155504 creator A5015791236 @default.
- W2103155504 creator A5029779967 @default.
- W2103155504 date "1991-07-01" @default.
- W2103155504 modified "2023-09-27" @default.
- W2103155504 title "Radiolabeling of Mycobacterium leprae lipids within schwannoma cells, a potential drug screening system" @default.
- W2103155504 cites W1574341924 @default.
- W2103155504 cites W1859442435 @default.
- W2103155504 cites W1918366594 @default.
- W2103155504 cites W1943547825 @default.
- W2103155504 cites W2021082718 @default.
- W2103155504 cites W2064650562 @default.
- W2103155504 cites W2084892412 @default.
- W2103155504 cites W2097393729 @default.
- W2103155504 cites W2152311269 @default.
- W2103155504 cites W2263288149 @default.
- W2103155504 doi "https://doi.org/10.1128/aac.35.7.1444" @default.
- W2103155504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/245187" @default.
- W2103155504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1929306" @default.
- W2103155504 hasPublicationYear "1991" @default.
- W2103155504 type Work @default.
- W2103155504 sameAs 2103155504 @default.
- W2103155504 citedByCount "0" @default.
- W2103155504 crossrefType "journal-article" @default.
- W2103155504 hasAuthorship W2103155504A5015679073 @default.
- W2103155504 hasAuthorship W2103155504A5015791236 @default.
- W2103155504 hasAuthorship W2103155504A5029779967 @default.
- W2103155504 hasBestOaLocation W21031555042 @default.
- W2103155504 hasConcept C185592680 @default.
- W2103155504 hasConcept C202751555 @default.
- W2103155504 hasConcept C203014093 @default.
- W2103155504 hasConcept C2777640609 @default.
- W2103155504 hasConcept C2779823659 @default.
- W2103155504 hasConcept C2780035454 @default.
- W2103155504 hasConcept C2780374374 @default.
- W2103155504 hasConcept C2780695269 @default.
- W2103155504 hasConcept C523546767 @default.
- W2103155504 hasConcept C54355233 @default.
- W2103155504 hasConcept C55493867 @default.
- W2103155504 hasConcept C81885089 @default.
- W2103155504 hasConcept C86803240 @default.
- W2103155504 hasConcept C89423630 @default.
- W2103155504 hasConcept C98274493 @default.
- W2103155504 hasConceptScore W2103155504C185592680 @default.
- W2103155504 hasConceptScore W2103155504C202751555 @default.
- W2103155504 hasConceptScore W2103155504C203014093 @default.
- W2103155504 hasConceptScore W2103155504C2777640609 @default.
- W2103155504 hasConceptScore W2103155504C2779823659 @default.
- W2103155504 hasConceptScore W2103155504C2780035454 @default.
- W2103155504 hasConceptScore W2103155504C2780374374 @default.
- W2103155504 hasConceptScore W2103155504C2780695269 @default.
- W2103155504 hasConceptScore W2103155504C523546767 @default.
- W2103155504 hasConceptScore W2103155504C54355233 @default.
- W2103155504 hasConceptScore W2103155504C55493867 @default.
- W2103155504 hasConceptScore W2103155504C81885089 @default.
- W2103155504 hasConceptScore W2103155504C86803240 @default.
- W2103155504 hasConceptScore W2103155504C89423630 @default.
- W2103155504 hasConceptScore W2103155504C98274493 @default.
- W2103155504 hasIssue "7" @default.
- W2103155504 hasLocation W21031555041 @default.
- W2103155504 hasLocation W21031555042 @default.
- W2103155504 hasOpenAccess W2103155504 @default.
- W2103155504 hasPrimaryLocation W21031555041 @default.
- W2103155504 hasRelatedWork W11032412 @default.
- W2103155504 hasRelatedWork W2084666832 @default.
- W2103155504 hasRelatedWork W2150815333 @default.
- W2103155504 hasRelatedWork W2410206652 @default.
- W2103155504 hasRelatedWork W2410382400 @default.
- W2103155504 hasRelatedWork W2410528819 @default.
- W2103155504 hasRelatedWork W2416606926 @default.
- W2103155504 hasRelatedWork W2443788039 @default.
- W2103155504 hasRelatedWork W2464465627 @default.
- W2103155504 hasRelatedWork W3019322471 @default.
- W2103155504 hasVolume "35" @default.
- W2103155504 isParatext "false" @default.
- W2103155504 isRetracted "false" @default.
- W2103155504 magId "2103155504" @default.
- W2103155504 workType "article" @default.