Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103156801> ?p ?o ?g. }
- W2103156801 abstract "The three-dimensional fold of Plasmodium falciparum (Pf) 20S proteasome is similar to yeast Saccharomyces cerevisiae 20S proteasome. The twenty eight subunits complex corresponding to two copies of seven distinct α and seven distinct β subunits shares >35% sequence identity with equivalent subunits of the yeast 20S proteasome. Bortezomib (Velcade®) - a known inhibitor of the three catalytic subunits; β1, β2, β5 of the yeast 20S proteasome can bind in the equivalent subunits of the Pf 20S proteasome and is in agreement with experimental results. The model defines the binding mode of the bortezomib inhibitor within the catalytic subunits of the Pf 20S proteasome and provides the structural basis for the design of Pf 20S proteasome-specific inhibitors. The substitutions associated within the catalytic subunits of Pf 20S proteasome relative to yeast 20S proteasome; Thr21-Ser, Thr22-Ser, Thr31-Ser, Thr35-Asn, Ala49-Ser (in β1 subunit), Ser20-Ala, Gln22-Glu (β2) and Thr21-Ser, Ala22-Met, Gln53-Leu (β5) may influence the relative caspase-like, tryptic-like and chymotryptic-like activities of the Pf 20S proteasome. The plasmodia-specific 'large' insert comprising fifty four amino acid residues (in β1 subunit) of the Pf 20S proteasome is distant from the catalytic sites." @default.
- W2103156801 created "2016-06-24" @default.
- W2103156801 creator A5006405527 @default.
- W2103156801 creator A5047098078 @default.
- W2103156801 creator A5053174646 @default.
- W2103156801 date "2013-10-26" @default.
- W2103156801 modified "2023-09-23" @default.
- W2103156801 title "Analysis of bortezomib inhibitor docked within the catalytic subunits of the Plasmodium falciparum 20S proteasome" @default.
- W2103156801 cites W136634311 @default.
- W2103156801 cites W1832030339 @default.
- W2103156801 cites W1969894269 @default.
- W2103156801 cites W1972076184 @default.
- W2103156801 cites W1978726512 @default.
- W2103156801 cites W1986191025 @default.
- W2103156801 cites W1987338737 @default.
- W2103156801 cites W1992174702 @default.
- W2103156801 cites W1992978957 @default.
- W2103156801 cites W1999119754 @default.
- W2103156801 cites W2005975820 @default.
- W2103156801 cites W2011457559 @default.
- W2103156801 cites W2015642465 @default.
- W2103156801 cites W2043943641 @default.
- W2103156801 cites W2046164706 @default.
- W2103156801 cites W2065283382 @default.
- W2103156801 cites W2067910590 @default.
- W2103156801 cites W2068696470 @default.
- W2103156801 cites W2073160234 @default.
- W2103156801 cites W2077322822 @default.
- W2103156801 cites W2081912151 @default.
- W2103156801 cites W2083280521 @default.
- W2103156801 cites W2091823485 @default.
- W2103156801 cites W2099242689 @default.
- W2103156801 cites W2105668062 @default.
- W2103156801 cites W2106882534 @default.
- W2103156801 cites W2111129974 @default.
- W2103156801 cites W2123163899 @default.
- W2103156801 cites W2123781000 @default.
- W2103156801 cites W2124560610 @default.
- W2103156801 cites W2131736388 @default.
- W2103156801 cites W2136735139 @default.
- W2103156801 cites W2158714788 @default.
- W2103156801 cites W2160129809 @default.
- W2103156801 cites W2163495162 @default.
- W2103156801 cites W2164710551 @default.
- W2103156801 cites W2166987747 @default.
- W2103156801 cites W2168708922 @default.
- W2103156801 cites W2178503716 @default.
- W2103156801 cites W2309654573 @default.
- W2103156801 cites W4211208250 @default.
- W2103156801 cites W4240401512 @default.
- W2103156801 cites W4255738047 @default.
- W2103156801 cites W95014119 @default.
- W2103156801 doi "https://doi.org/10.1186/2193-1801-2-566" @default.
- W2103156801 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3825223" @default.
- W2103156801 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24255860" @default.
- W2103156801 hasPublicationYear "2013" @default.
- W2103156801 type Work @default.
- W2103156801 sameAs 2103156801 @default.
- W2103156801 citedByCount "3" @default.
- W2103156801 countsByYear W21031568012017 @default.
- W2103156801 countsByYear W21031568012018 @default.
- W2103156801 countsByYear W21031568012023 @default.
- W2103156801 crossrefType "journal-article" @default.
- W2103156801 hasAuthorship W2103156801A5006405527 @default.
- W2103156801 hasAuthorship W2103156801A5047098078 @default.
- W2103156801 hasAuthorship W2103156801A5053174646 @default.
- W2103156801 hasBestOaLocation W21031568011 @default.
- W2103156801 hasConcept C104292427 @default.
- W2103156801 hasConcept C104317684 @default.
- W2103156801 hasConcept C185592680 @default.
- W2103156801 hasConcept C203014093 @default.
- W2103156801 hasConcept C27740335 @default.
- W2103156801 hasConcept C2776364478 @default.
- W2103156801 hasConcept C2777478702 @default.
- W2103156801 hasConcept C2777576037 @default.
- W2103156801 hasConcept C2778048844 @default.
- W2103156801 hasConcept C2778367456 @default.
- W2103156801 hasConcept C2778371730 @default.
- W2103156801 hasConcept C2779222958 @default.
- W2103156801 hasConcept C55493867 @default.
- W2103156801 hasConcept C86803240 @default.
- W2103156801 hasConceptScore W2103156801C104292427 @default.
- W2103156801 hasConceptScore W2103156801C104317684 @default.
- W2103156801 hasConceptScore W2103156801C185592680 @default.
- W2103156801 hasConceptScore W2103156801C203014093 @default.
- W2103156801 hasConceptScore W2103156801C27740335 @default.
- W2103156801 hasConceptScore W2103156801C2776364478 @default.
- W2103156801 hasConceptScore W2103156801C2777478702 @default.
- W2103156801 hasConceptScore W2103156801C2777576037 @default.
- W2103156801 hasConceptScore W2103156801C2778048844 @default.
- W2103156801 hasConceptScore W2103156801C2778367456 @default.
- W2103156801 hasConceptScore W2103156801C2778371730 @default.
- W2103156801 hasConceptScore W2103156801C2779222958 @default.
- W2103156801 hasConceptScore W2103156801C55493867 @default.
- W2103156801 hasConceptScore W2103156801C86803240 @default.
- W2103156801 hasIssue "1" @default.
- W2103156801 hasLocation W21031568011 @default.
- W2103156801 hasLocation W21031568012 @default.
- W2103156801 hasLocation W21031568013 @default.
- W2103156801 hasLocation W21031568014 @default.