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• W2103158005 endingPage "1973" @default.
• W2103158005 startingPage "1966" @default.
• W2103158005 abstract "The Drosophila body organizer Bicoid (Bcd) is a maternal homeodomain protein. It forms a concentration gradient along the longitudinal axis of the preblastoderm embryo and activates early zygotic segmentation genes in a threshold-dependent fashion. In addition, Bcd acts as a translational repressor of maternal caudal (cad) mRNA in the anterior region of the embryo. This process involves a distinct Bcd-binding region (BBR) in the 3' untranslated region (UTR) of cad mRNA. Using cotransfection assays, we found that Bcd represses translation in a cap-dependent manner. Bcd-dependent translational repression involves a portion of the PEST motif of Bcd, a conserved protein motif best known for its function in protein degradation. Rescue experiments with Bcd-deficient embryos expressing transgene-derived Bcd mutants indicate that amino acid replacements within the C-terminal portion of the PEST motif prevent translational repression of cad mRNA but allow for Bcd-dependent transcriptional activation. Thus, Bcd contains separable protein domains for transcriptional and translational regulation of target genes. Maternally-derived cad protein in the anterior region of embryos interferes with head morphogenesis, showing that cad mRNA suppression by Bcd is an important control event during early Drosophila embryogenesis." @default.
• W2103158005 created "2016-06-24" @default.
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• W2103158005 date "1999-04-01" @default.
• W2103158005 modified "2023-10-05" @default.
• W2103158005 title "Sequence interval within the PEST motif of Bicoid is important for translational repression of caudal mRNA in the anterior region of the Drosophila embryo" @default.
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• W2103158005 doi "https://doi.org/10.1093/emboj/18.7.1966" @default.
• W2103158005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1171281" @default.
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