Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103163128> ?p ?o ?g. }
- W2103163128 endingPage "e1000283" @default.
- W2103163128 startingPage "e1000283" @default.
- W2103163128 abstract "The endosomal pathway in neuronal dendrites is essential for membrane receptor trafficking and proper synaptic function and plasticity. However, the molecular mechanisms that organize specific endocytic trafficking routes are poorly understood. Here, we identify GRIP-associated protein-1 (GRASP-1) as a neuron-specific effector of Rab4 and key component of the molecular machinery that coordinates recycling endosome maturation in dendrites. We show that GRASP-1 is necessary for AMPA receptor recycling, maintenance of spine morphology, and synaptic plasticity. At the molecular level, GRASP-1 segregates Rab4 from EEA1/Neep21/Rab5-positive early endosomal membranes and coordinates the coupling to Rab11-labelled recycling endosomes by interacting with the endosomal SNARE syntaxin 13. We propose that GRASP-1 connects early and late recycling endosomal compartments by forming a molecular bridge between Rab-specific membrane domains and the endosomal SNARE machinery. The data uncover a new mechanism to achieve specificity and directionality in neuronal membrane receptor trafficking." @default.
- W2103163128 created "2016-06-24" @default.
- W2103163128 creator A5000837316 @default.
- W2103163128 creator A5002046964 @default.
- W2103163128 creator A5004993017 @default.
- W2103163128 creator A5005208872 @default.
- W2103163128 creator A5008631765 @default.
- W2103163128 creator A5009471862 @default.
- W2103163128 creator A5025164063 @default.
- W2103163128 creator A5040172417 @default.
- W2103163128 creator A5040599736 @default.
- W2103163128 creator A5042911773 @default.
- W2103163128 creator A5053603496 @default.
- W2103163128 creator A5057339032 @default.
- W2103163128 creator A5058356091 @default.
- W2103163128 creator A5060021844 @default.
- W2103163128 creator A5084592194 @default.
- W2103163128 creator A5087560400 @default.
- W2103163128 creator A5089383490 @default.
- W2103163128 date "2010-01-19" @default.
- W2103163128 modified "2023-10-14" @default.
- W2103163128 title "Neuron Specific Rab4 Effector GRASP-1 Coordinates Membrane Specialization and Maturation of Recycling Endosomes" @default.
- W2103163128 cites W1488868467 @default.
- W2103163128 cites W1595083713 @default.
- W2103163128 cites W179329376 @default.
- W2103163128 cites W179352461 @default.
- W2103163128 cites W1963923544 @default.
- W2103163128 cites W1965507972 @default.
- W2103163128 cites W1967271803 @default.
- W2103163128 cites W1977253956 @default.
- W2103163128 cites W1978391620 @default.
- W2103163128 cites W1979688230 @default.
- W2103163128 cites W1988741762 @default.
- W2103163128 cites W1992336474 @default.
- W2103163128 cites W1994668150 @default.
- W2103163128 cites W1995621239 @default.
- W2103163128 cites W1995680954 @default.
- W2103163128 cites W1997362427 @default.
- W2103163128 cites W1998083136 @default.
- W2103163128 cites W2009071652 @default.
- W2103163128 cites W2010850820 @default.
- W2103163128 cites W2014907593 @default.
- W2103163128 cites W2014923822 @default.
- W2103163128 cites W2015256188 @default.
- W2103163128 cites W2021271933 @default.
- W2103163128 cites W2027436298 @default.
- W2103163128 cites W2029149519 @default.
- W2103163128 cites W2038783205 @default.
- W2103163128 cites W2044208012 @default.
- W2103163128 cites W2047277267 @default.
- W2103163128 cites W2049926325 @default.
- W2103163128 cites W2059367016 @default.
- W2103163128 cites W2059418306 @default.
- W2103163128 cites W2063512037 @default.
- W2103163128 cites W2064880862 @default.
- W2103163128 cites W2065378127 @default.
- W2103163128 cites W2066254967 @default.
- W2103163128 cites W2071318481 @default.
- W2103163128 cites W2075318390 @default.
- W2103163128 cites W2081762479 @default.
- W2103163128 cites W2081861611 @default.
- W2103163128 cites W2086698861 @default.
- W2103163128 cites W2087728854 @default.
- W2103163128 cites W2091599508 @default.
- W2103163128 cites W2092528157 @default.
- W2103163128 cites W2092759474 @default.
- W2103163128 cites W2094625991 @default.
- W2103163128 cites W2095220436 @default.
- W2103163128 cites W2106015922 @default.
- W2103163128 cites W2107625241 @default.
- W2103163128 cites W2110522985 @default.
- W2103163128 cites W2110728570 @default.
- W2103163128 cites W2116382231 @default.
- W2103163128 cites W2123591482 @default.
- W2103163128 cites W2126162952 @default.
- W2103163128 cites W2128574573 @default.
- W2103163128 cites W2133623572 @default.
- W2103163128 cites W2135004571 @default.
- W2103163128 cites W2135744973 @default.
- W2103163128 cites W2138435892 @default.
- W2103163128 cites W2140552779 @default.
- W2103163128 cites W2154100802 @default.
- W2103163128 cites W2157693053 @default.
- W2103163128 cites W2160775987 @default.
- W2103163128 cites W2161442189 @default.
- W2103163128 cites W2167221791 @default.
- W2103163128 cites W2168112405 @default.
- W2103163128 cites W4211214945 @default.
- W2103163128 doi "https://doi.org/10.1371/journal.pbio.1000283" @default.
- W2103163128 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2933131" @default.
- W2103163128 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20098723" @default.
- W2103163128 hasPublicationYear "2010" @default.
- W2103163128 type Work @default.
- W2103163128 sameAs 2103163128 @default.
- W2103163128 citedByCount "83" @default.
- W2103163128 countsByYear W21031631282012 @default.
- W2103163128 countsByYear W21031631282013 @default.
- W2103163128 countsByYear W21031631282014 @default.