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- W2103163387 abstract "Precise staging of neuroendocrine tumors (NET) using positron emission tomography (PET) tracers visualizing their specific metabolic activity is of interest. Besides [18F]FDOPA, staging NET with carbon-11 labeled 5-hydroxytryptophan (5-HTP) is reported in recent literature. We implemented the multi-enzymatic synthesis of enantiomerically pure [11C]-L-5-HTP on a Zymark robotic system to compare both tracers in patient studies. [11C]-5-HTP can be synthesized in up to 24% radiochemical yields (EOB). Average specific activity is 44 000 GBq/mmol in ca. 50 min from [11C]methyl iodide in radiochemical purities >99 %. The synthesis of 5-HTP is difficult due to its multi-enzymatic reaction steps but typical yields can be achieved of ca. 400 MBq. [11C]-5-HTP is now reliably used in ongoing studies for staging NET. Copyright © 2006 John Wiley & Sons, Ltd." @default.
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- W2103163387 date "2006-01-01" @default.
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- W2103163387 title "Development of a reliable remote-controlled synthesis ofβ-[11C]-5-hydroxy-L-tryptophan on a Zymark robotic system" @default.
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- W2103163387 doi "https://doi.org/10.1002/jlcr.1110" @default.
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