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• W2103163836 endingPage "972" @default.
• W2103163836 startingPage "972" @default.
• W2103163836 abstract "<h3>Background</h3> The isoprostane 8,12-<i>iso</i>-iPF_2α-VI, a specific marker of in vivo lipid peroxidation, is increased in Alzheimer disease (AD). The pathological changes associated with AD have a long silent phase before the appearance of clinical symptoms. Several studies have shown that AD is preceded by a prodromal phase characterized by mild cognitive impairment (MCI). <h3>Objective</h3> To investigate levels of this biomarker in subjects with MCI. <h3>Design and Main Outcome Measures</h3> Using gas chromatography–mass spectrometry analysis, we measured 8,12-<i>iso</i>-iPF_2α-VI levels in urine, plasma, and cerebrospinal fluid of patients with AD, subjects with MCI, and cognitively normal elderly subjects. <h3>Setting and Patients</h3> Subjects attending the Memory Disorders Clinic. <h3>Results</h3> We found significantly higher 8,12-<i>iso</i>-iPF_2α-VI levels in cerebrospinal fluid, plasma, and urine of subjects with MCI compared with cognitively normal elderly subjects. <h3>Conclusions</h3> These results imply that individuals with MCI have increased brain oxidative damage before the onset of symptomatic dementia. Measurement of this isoprostane may identify a subgroup of patients with MCI with increased lipid peroxidation who are at increased risk to progress to symptomatic AD." @default.
• W2103163836 created "2016-06-24" @default.
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• W2103163836 date "2002-06-01" @default.
• W2103163836 modified "2023-10-18" @default.
• W2103163836 title "Increase of Brain Oxidative Stress in Mild Cognitive Impairment" @default.
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• W2103163836 doi "https://doi.org/10.1001/archneur.59.6.972" @default.
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