FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103168327> ?p ?o ?g. }

• W2103168327 endingPage "817" @default.
• W2103168327 startingPage "811" @default.
• W2103168327 abstract "2-Difluoromethylornithine totally prevented any increases in putrescine and spermidine concentrations in the ventral prostate of castrated rats during a 6-day testosterone treatment. Prostatic ornithine decarboxylase activity was inhibited by 80%, whereas S-adenosylmethionine decarboxylase was stimulated by more than 9-fold. In seminal vesicle, the inhibition of putrescine and spermidine accumulation, as well as of ornithine decarboxylase activity, was only minimal, and no stimulation of S-adenosylmethionine decarboxylase was observed. Administration of methylglyoxal bis(guanylhydrazone) to castrated androgen-treated rats resulted in a marked increase in concentrations of all prostatic polyamines. Prostatic ornithine decarboxylase activity was nearly 2 times and adenosylmethionine decarboxylase activity 9 times higher than that of the testosterone-treated animals. In contrast with ventral prostate, methylglyoxal bis(guanylhydrazone) treatment inhibited moderately the accumulation of spermidine and spermine in seminal vesicle, although both ornithine decarboxylase and S-adenosylmethionine decarboxylase activities were stimulated. Difluoromethylornithine inhibited significantly the weight gain of ventral prostate, but methylglyoxal bis(guanylhydrazone) produced a substantial increase in prostatic weight. These changes were largely due to the fact that the volume of prostatic secretion was greatly decreased by difluoromethylornithine, whereas methylglyoxal bis(guanylhydrazone) increased the amount of secretion. Treatment with difluoromethylornithine strikingly increased the methylglyoxal bis(guanylhydrazone) content of both ventral prostate and seminal vesicle, but even under these conditions the drug concentration remained low in comparison with other tissues. The results indicate that a combined use of these two polyamine anti-metabolites does not necessarily result in a synergistic growth inhibition of the androgen-induced growth of male accessory sexual glands." @default.
• W2103168327 created "2016-06-24" @default.
• W2103168327 creator A5002560406 @default.
• W2103168327 creator A5022613799 @default.
• W2103168327 creator A5069136326 @default.
• W2103168327 date "1984-05-01" @default.
• W2103168327 modified "2023-09-26" @default.
• W2103168327 title "Differential effects of 2-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the testosterone-induced growth of ventral prostate and seminal vesicles of castrated rats" @default.
• W2103168327 cites W1477862386 @default.
• W2103168327 cites W1493938658 @default.
• W2103168327 cites W1513354202 @default.
• W2103168327 cites W1529085592 @default.
• W2103168327 cites W155569352 @default.
• W2103168327 cites W1576879289 @default.
• W2103168327 cites W1755026595 @default.
• W2103168327 cites W1775749144 @default.
• W2103168327 cites W1964124475 @default.
• W2103168327 cites W1969591016 @default.
• W2103168327 cites W1974954882 @default.
• W2103168327 cites W1987291084 @default.
• W2103168327 cites W2006745481 @default.
• W2103168327 cites W2008468165 @default.
• W2103168327 cites W2018365717 @default.
• W2103168327 cites W2019382570 @default.
• W2103168327 cites W2063193308 @default.
• W2103168327 cites W2072962846 @default.
• W2103168327 cites W2080707821 @default.
• W2103168327 cites W2083786151 @default.
• W2103168327 cites W2115713071 @default.
• W2103168327 cites W2229052801 @default.
• W2103168327 cites W2340148597 @default.
• W2103168327 cites W2410974171 @default.
• W2103168327 cites W2418960301 @default.
• W2103168327 cites W2462333321 @default.
• W2103168327 doi "https://doi.org/10.1042/bj2190811" @default.
• W2103168327 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1153548" @default.
• W2103168327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6430275" @default.
• W2103168327 hasPublicationYear "1984" @default.
• W2103168327 type Work @default.
• W2103168327 sameAs 2103168327 @default.
• W2103168327 citedByCount "10" @default.
• W2103168327 crossrefType "journal-article" @default.
• W2103168327 hasAuthorship W2103168327A5002560406 @default.
• W2103168327 hasAuthorship W2103168327A5022613799 @default.
• W2103168327 hasAuthorship W2103168327A5069136326 @default.
• W2103168327 hasBestOaLocation W21031683272 @default.
• W2103168327 hasConcept C121289238 @default.
• W2103168327 hasConcept C121608353 @default.
• W2103168327 hasConcept C126322002 @default.
• W2103168327 hasConcept C134018914 @default.
• W2103168327 hasConcept C181199279 @default.
• W2103168327 hasConcept C185592680 @default.
• W2103168327 hasConcept C2776109719 @default.
• W2103168327 hasConcept C2776235491 @default.
• W2103168327 hasConcept C2776796294 @default.
• W2103168327 hasConcept C2777167505 @default.
• W2103168327 hasConcept C2777468819 @default.
• W2103168327 hasConcept C2777497464 @default.
• W2103168327 hasConcept C2777911890 @default.
• W2103168327 hasConcept C2778592357 @default.
• W2103168327 hasConcept C2779279991 @default.
• W2103168327 hasConcept C2780115381 @default.
• W2103168327 hasConcept C2780944845 @default.
• W2103168327 hasConcept C2781171107 @default.
• W2103168327 hasConcept C515207424 @default.
• W2103168327 hasConcept C55493867 @default.
• W2103168327 hasConcept C71315377 @default.
• W2103168327 hasConcept C71924100 @default.
• W2103168327 hasConcept C86803240 @default.
• W2103168327 hasConceptScore W2103168327C121289238 @default.
• W2103168327 hasConceptScore W2103168327C121608353 @default.
• W2103168327 hasConceptScore W2103168327C126322002 @default.
• W2103168327 hasConceptScore W2103168327C134018914 @default.
• W2103168327 hasConceptScore W2103168327C181199279 @default.
• W2103168327 hasConceptScore W2103168327C185592680 @default.
• W2103168327 hasConceptScore W2103168327C2776109719 @default.
• W2103168327 hasConceptScore W2103168327C2776235491 @default.
• W2103168327 hasConceptScore W2103168327C2776796294 @default.
• W2103168327 hasConceptScore W2103168327C2777167505 @default.
• W2103168327 hasConceptScore W2103168327C2777468819 @default.
• W2103168327 hasConceptScore W2103168327C2777497464 @default.
• W2103168327 hasConceptScore W2103168327C2777911890 @default.
• W2103168327 hasConceptScore W2103168327C2778592357 @default.
• W2103168327 hasConceptScore W2103168327C2779279991 @default.
• W2103168327 hasConceptScore W2103168327C2780115381 @default.
• W2103168327 hasConceptScore W2103168327C2780944845 @default.
• W2103168327 hasConceptScore W2103168327C2781171107 @default.
• W2103168327 hasConceptScore W2103168327C515207424 @default.
• W2103168327 hasConceptScore W2103168327C55493867 @default.
• W2103168327 hasConceptScore W2103168327C71315377 @default.
• W2103168327 hasConceptScore W2103168327C71924100 @default.
• W2103168327 hasConceptScore W2103168327C86803240 @default.
• W2103168327 hasIssue "3" @default.
• W2103168327 hasLocation W21031683271 @default.
• W2103168327 hasLocation W21031683272 @default.
• W2103168327 hasLocation W21031683273 @default.
• W2103168327 hasLocation W21031683274 @default.
• W2103168327 hasOpenAccess W2103168327 @default.

• next