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- W2103169939 abstract "The present study describes the development of a validated RP-HPLC method for the determination of 5-fluorouracil in presence of its degradation products or other pharmaceutical excipients. Stress studies were performed on 5-fluorouracil and it was found that it degrades sufficiently in alkaline conditions, while negligible degradation was observed in acidic, neutral, oxidative and photolytic conditions. The peaks of the degradation products were not observed in the chromatogram due to the nonchromophoric nature of the degradation moiety formed. The separations were carried out on a C-18 reversed phase column (Phenomenex; Prodigy ODS3V, 250x4.6 mm, 5 mu) using 50mM KH(2)PO(4) (pH, 5.0) as mobile phase at a flow rate of 1.2 ml/min and temperature of 30 degrees . The wavelength of detection was 254 nm. A retention time of nearly 6 minutes was obtained. Analytical validation parameters such as specificity and selectivity, linearity, accuracy and precision were evaluated. The calibration curve for 5-fluorouracil was linear (r(2)=0.999+/-0.0005) from range of 10 mug/ml to 100 mug/ml. Relative standard deviation values for all the key parameters, was less than 2.0 %. The recovery of the drug after standard addition to the degraded sample was found to be 104.69%. Thus, the developed RP-HPLC method was found to be suitable for the determination of 5-fluorouracil in bulk as well as stability samples of the pharmaceutical dosage forms containing various excipients." @default.
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- W2103169939 date "2009-01-01" @default.
- W2103169939 modified "2023-10-13" @default.
- W2103169939 title "A stability-indicating RP-HPLC assay method for 5-fluorouracil" @default.
- W2103169939 cites W2014270163 @default.
- W2103169939 doi "https://doi.org/10.4103/0250-474x.59544" @default.
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