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• W2103171514 abstract "Parasite-encoded variant surface antigens (VSAs) like the var gene–encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P. falciparum malaria. Parasites causing severe malaria in nonimmune patients tend to express a restricted subset of VSA (VSASM) that differs from VSA associated with uncomplicated malaria and asymptomatic infection (VSAUM). We compared var gene transcription in unselected P. falciparum clone 3D7 expressing VSAUM to in vitro–selected sublines expressing VSASM to identify PfEMP1 responsible for the VSASM phenotype. Expression of VSASM was accompanied by up-regulation of Group A var genes. The most prominently up-regulated Group A gene (PFD1235w/MAL7P1.1) was translated into a protein expressed on the infected RBC surface. The proteins encoded by Group A var genes, such as PFD1235w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P. falciparum malaria." @default.
• W2103171514 created "2016-06-24" @default.
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• W2103171514 date "2004-05-03" @default.
• W2103171514 modified "2023-10-11" @default.
• W2103171514 title "Plasmodium falciparum Associated with Severe Childhood Malaria Preferentially Expresses PfEMP1 Encoded by Group A var Genes" @default.
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• W2103171514 doi "https://doi.org/10.1084/jem.20040274" @default.
• W2103171514 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2211911" @default.
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• W2103171514 hasPublicationYear "2004" @default.
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