FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103172237> ?p ?o ?g. }

• W2103172237 endingPage "960" @default.
• W2103172237 startingPage "951" @default.
• W2103172237 abstract "Both physiological and pharmacological levels of the pineal hormone melatonin exhibit substantial anticancer activity in tissue-isolated rat hepatoma 7288CTC via melatonin receptor-mediated blockade of tumor uptake of linoleic acid (LA) and its metabolism to the mitogenic signaling molecule 13-hydroxyoctadecadienoic acid (13-HODE). Melatonin is also present in significant amounts in edible plants and is supplied in nutritional supplements. We confirmed the presence of significant quantities of melatonin in 20 varieties of edible plants. In pinealectomized tumor-free rats, 3 weeks of ingestion of either 5 or 50 microg/day of melatonin contained in a semi-purified diet resulted in a dose-dependent elevation in steady-state plasma melatonin levels within the nocturnal physiological range. In pineal-intact tumor-bearing rats, the daily intake of 5 microg/day of melatonin for 3 weeks resulted in an enhanced amplitude and duration of the nocturnal melatonin levels within physiological circulating limits. The nocturnal melatonin amplitude in rats ingesting 500 ng of melatonin/day remained within the physiological range. A dose-related increase in tumor concentrations of melatonin occurred in animals ingesting melatonin from the diet. Perfusion of tumors in situ with physiological, nocturnal blood levels of melatonin resulted in a mean 31% uptake and retention of the melatonin. Chronic ingestion of 50 ng, 500 ng or 5 microg of melatonin/day supplied in a semi-purified 5% corn oil diet led to a significant dose-dependent reduction in the rates of tumor total fatty acid uptake, LA uptake, 13-HODE production and tumor growth. The co-ingestion of melatonin receptor antagonist S20928 completely blocked the effects and prevented the intra-tumoral accumulation of melatonin. Melatonin receptor-mediated suppression of tumor growth, LA uptake and metabolism, and stimulation of tumor melatonin uptake and retention in response to the dietary intake of phytomelatonin from edible plants or melatonin from nutritional supplements, could play an important role in cancer growth prevention." @default.
• W2103172237 created "2016-06-24" @default.
• W2103172237 creator A5000460858 @default.
• W2103172237 creator A5016402426 @default.
• W2103172237 creator A5071281736 @default.
• W2103172237 creator A5086350131 @default.
• W2103172237 date "2004-02-04" @default.
• W2103172237 modified "2023-10-04" @default.
• W2103172237 title "Melatonin uptake and growth prevention in rat hepatoma 7288CTC in response to dietary melatonin: melatonin receptor-mediated inhibition of tumor linoleic acid metabolism to the growth signaling molecule 13-hydroxyoctadecadienoic acid and the potential role of phytomelatonin" @default.
• W2103172237 cites W1023444678 @default.
• W2103172237 cites W1505346873 @default.
• W2103172237 cites W156956281 @default.
• W2103172237 cites W1575584337 @default.
• W2103172237 cites W1590249399 @default.
• W2103172237 cites W1783498278 @default.
• W2103172237 cites W1964698623 @default.
• W2103172237 cites W1967419252 @default.
• W2103172237 cites W1970985133 @default.
• W2103172237 cites W1974354000 @default.
• W2103172237 cites W1974946679 @default.
• W2103172237 cites W1975835974 @default.
• W2103172237 cites W1980673490 @default.
• W2103172237 cites W1989418616 @default.
• W2103172237 cites W2010038812 @default.
• W2103172237 cites W2011179761 @default.
• W2103172237 cites W2013551886 @default.
• W2103172237 cites W2016556735 @default.
• W2103172237 cites W2017078849 @default.
• W2103172237 cites W2017728305 @default.
• W2103172237 cites W2026614124 @default.
• W2103172237 cites W2030795161 @default.
• W2103172237 cites W2034416069 @default.
• W2103172237 cites W2045208242 @default.
• W2103172237 cites W2049958927 @default.
• W2103172237 cites W2054103716 @default.
• W2103172237 cites W2054932991 @default.
• W2103172237 cites W2057572154 @default.
• W2103172237 cites W2062679222 @default.
• W2103172237 cites W2070827598 @default.
• W2103172237 cites W2071469400 @default.
• W2103172237 cites W2072476951 @default.
• W2103172237 cites W2076429988 @default.
• W2103172237 cites W2085332079 @default.
• W2103172237 cites W2090861511 @default.
• W2103172237 cites W2092572657 @default.
• W2103172237 cites W2098243593 @default.
• W2103172237 cites W2105864875 @default.
• W2103172237 cites W2106391360 @default.
• W2103172237 cites W2110702160 @default.
• W2103172237 cites W2113075966 @default.
• W2103172237 cites W2117281659 @default.
• W2103172237 cites W2125220776 @default.
• W2103172237 cites W2135167537 @default.
• W2103172237 cites W2136350449 @default.
• W2103172237 cites W2141404207 @default.
• W2103172237 cites W2152119541 @default.
• W2103172237 cites W2153825511 @default.
• W2103172237 cites W2156261924 @default.
• W2103172237 cites W2162934051 @default.
• W2103172237 cites W2163134691 @default.
• W2103172237 cites W2168526937 @default.
• W2103172237 cites W2171273651 @default.
• W2103172237 cites W2171722927 @default.
• W2103172237 cites W2315650305 @default.
• W2103172237 cites W2323059839 @default.
• W2103172237 cites W2401855602 @default.
• W2103172237 cites W2409352638 @default.
• W2103172237 cites W2477115003 @default.
• W2103172237 cites W2496855790 @default.
• W2103172237 cites W591946530 @default.
• W2103172237 cites W605966495 @default.
• W2103172237 cites W630385254 @default.
• W2103172237 cites W68275011 @default.
• W2103172237 doi "https://doi.org/10.1093/carcin/bgh090" @default.
• W2103172237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14754876" @default.
• W2103172237 hasPublicationYear "2004" @default.
• W2103172237 type Work @default.
• W2103172237 sameAs 2103172237 @default.
• W2103172237 citedByCount "113" @default.
• W2103172237 countsByYear W21031722372012 @default.
• W2103172237 countsByYear W21031722372013 @default.
• W2103172237 countsByYear W21031722372014 @default.
• W2103172237 countsByYear W21031722372015 @default.
• W2103172237 countsByYear W21031722372016 @default.
• W2103172237 countsByYear W21031722372017 @default.
• W2103172237 countsByYear W21031722372018 @default.
• W2103172237 countsByYear W21031722372019 @default.
• W2103172237 countsByYear W21031722372020 @default.
• W2103172237 countsByYear W21031722372021 @default.
• W2103172237 countsByYear W21031722372022 @default.
• W2103172237 countsByYear W21031722372023 @default.
• W2103172237 crossrefType "journal-article" @default.
• W2103172237 hasAuthorship W2103172237A5000460858 @default.
• W2103172237 hasAuthorship W2103172237A5016402426 @default.
• W2103172237 hasAuthorship W2103172237A5071281736 @default.
• W2103172237 hasAuthorship W2103172237A5086350131 @default.
• W2103172237 hasBestOaLocation W21031722371 @default.
• W2103172237 hasConcept C126322002 @default.

• next