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- W2103172302 abstract "Spontaneous pregnancy loss affects 15–18% of couples, and a number of potential causes are being discussed. The purpose of the present study was to assess if angiogenic disorders in the decidua of early human pregnancy could be related to spontaneous abortions. First trimester human decidua from elective terminations of normally progressing pregnancies and from missed abortions were investigated immunohistochemically. We quantified vessel density in decidua from normal pregnancies and from abortions by von Willebrand factor (vWF), platelet endothelial cell adhesion molecule (PECAM-1) and CD34 staining. Decidual blood vessel expression of αvβ3 integrin was also investigated. Significant increase (P < 0.02) in vessel density was observed in decidua parietalis of abortions, compared to decidua basalis. This increase was detected on slides stained for vWF and CD34, but not for PECAM-1. We observed a 15% increase analysing with vWF and a 77% increase with CD34 staining. αvβ3 integrin expression was not significantly different, neither in decidua parietalis from abortion, nor parietalis from normal pregnancies. Our data suggest that the increased vascularization in decidua parietalis from abortions could reflect complex disorders, such as specific cytokine expressions and hypoxia phenomena during the development of the decidua." @default.
- W2103172302 created "2016-06-24" @default.
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- W2103172302 date "1999-06-01" @default.
- W2103172302 modified "2023-10-18" @default.
- W2103172302 title "Increased blood vessel density in decidua parietalis is associated with spontaneous human first trimester abortion" @default.
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- W2103172302 doi "https://doi.org/10.1093/humrep/14.6.1628" @default.
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