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• W2103172754 abstract "Germline <i>CDH1</i> mutations confer a high lifetime risk of developing diffuse gastric (DGC) and lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic testing, surgery, surveillance strategies, pathology reporting and the patient9s perspective on multiple aspects, including diet post gastrectomy. The updated guidelines include revised <i>CDH1</i> testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). Additionally, <i>CDH1</i> testing could be considered in patients with bilateral or familial LBC before the age of 50, patients with DGC and cleft lip/palate, and those with precursor lesions for signet ring cell carcinoma. Given the high mortality associated with invasive disease, prophylactic total gastrectomy at a centre of expertise is advised for individuals with pathogenic <i>CDH1</i> mutations. Breast cancer surveillance with annual breast MRI starting at age 30 for women with a <i>CDH1</i> mutation is recommended. Standardised endoscopic surveillance in experienced centres is recommended for those opting not to have gastrectomy at the current time, those with <i>CDH1</i> variants of uncertain significance and those that fulfil hereditary DGC criteria without germline <i>CDH1</i> mutations. Expert histopathological confirmation of (early) signet ring cell carcinoma is recommended. The impact of gastrectomy and mastectomy should not be underestimated; these can have severe consequences on a psychological, physiological and metabolic level. Nutritional problems should be carefully monitored." @default.
• W2103172754 created "2016-06-24" @default.
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• W2103172754 date "2015-05-15" @default.
• W2103172754 modified "2023-10-17" @default.
• W2103172754 title "Hereditary diffuse gastric cancer: updated clinical guidelines with an emphasis on germline<i>CDH1</i>mutation carriers" @default.
• W2103172754 cites W1580633081 @default.
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• W2103172754 cites W1879957538 @default.
• W2103172754 cites W1965876549 @default.
• W2103172754 cites W1967099505 @default.
• W2103172754 cites W1969052633 @default.
• W2103172754 cites W1972927589 @default.
• W2103172754 cites W1975276361 @default.
• W2103172754 cites W1979488027 @default.
• W2103172754 cites W1981344425 @default.
• W2103172754 cites W1981520497 @default.
• W2103172754 cites W1983590366 @default.
• W2103172754 cites W1984551440 @default.
• W2103172754 cites W1990277130 @default.
• W2103172754 cites W1991932352 @default.
• W2103172754 cites W1997036826 @default.
• W2103172754 cites W1999824539 @default.
• W2103172754 cites W1999866417 @default.
• W2103172754 cites W2004219570 @default.
• W2103172754 cites W2012750775 @default.
• W2103172754 cites W2013602047 @default.
• W2103172754 cites W2018130645 @default.
• W2103172754 cites W2019205292 @default.
• W2103172754 cites W2021795276 @default.
• W2103172754 cites W2024590196 @default.
• W2103172754 cites W2025402368 @default.
• W2103172754 cites W2026741338 @default.
• W2103172754 cites W2027206828 @default.
• W2103172754 cites W2030438898 @default.
• W2103172754 cites W2031340144 @default.
• W2103172754 cites W2035731110 @default.
• W2103172754 cites W2037651828 @default.
• W2103172754 cites W2038847731 @default.
• W2103172754 cites W2046423523 @default.
• W2103172754 cites W2047928824 @default.
• W2103172754 cites W2048858446 @default.
• W2103172754 cites W2049247319 @default.
• W2103172754 cites W2050729751 @default.
• W2103172754 cites W2054882425 @default.
• W2103172754 cites W2055423741 @default.
• W2103172754 cites W2055850634 @default.
• W2103172754 cites W2058226274 @default.
• W2103172754 cites W2059284780 @default.
• W2103172754 cites W2060266620 @default.
• W2103172754 cites W2060608740 @default.

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