Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103173075> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2103173075 endingPage "449" @default.
- W2103173075 startingPage "442" @default.
- W2103173075 abstract "The effects of covalent cross-linkers on the enzyme, coproporphyrinogen oxidase, had been previously studied but their role in protecting the enzyme from protease cleavage has not been evaluated. Therefore, we examined how the cross-linker bis (sulfosuccinimidyl) suberate (BS3) affects the ability of trypsin to digest purified, wild type recombinant human coproporphyrinogen oxidase and selected mutants. Following incubation, the apparent molecular weights of peptides were evaluated by SDS-PAGE and enzymatic activity was assessed by spectroscopy following HPLC. For both wild type and mutants, the results indicated that the cross-linker was indeed able to protect against trypsin digestion relative to the enzyme incubated with trypsin in the absence of the cross-linker. These data have implications for the episodic nature of porphyria." @default.
- W2103173075 created "2016-06-24" @default.
- W2103173075 creator A5023185733 @default.
- W2103173075 creator A5024473758 @default.
- W2103173075 creator A5025825244 @default.
- W2103173075 creator A5031574077 @default.
- W2103173075 creator A5046617050 @default.
- W2103173075 date "2008-04-01" @default.
- W2103173075 modified "2023-09-26" @default.
- W2103173075 title "Protective Effects of Covalent Cross-Linking on Proteolysis of Human Coproporphyrinogen Oxidase and Implications for Porphyria" @default.
- W2103173075 cites W1539649121 @default.
- W2103173075 cites W1551072755 @default.
- W2103173075 cites W1998591058 @default.
- W2103173075 cites W1999365380 @default.
- W2103173075 cites W2005529704 @default.
- W2103173075 cites W2025221775 @default.
- W2103173075 cites W2039635116 @default.
- W2103173075 cites W2041537224 @default.
- W2103173075 cites W2043933835 @default.
- W2103173075 cites W2070116787 @default.
- W2103173075 cites W2081957391 @default.
- W2103173075 cites W2097773417 @default.
- W2103173075 cites W2164376253 @default.
- W2103173075 cites W2167086805 @default.
- W2103173075 cites W2217387567 @default.
- W2103173075 cites W2806071557 @default.
- W2103173075 doi "https://doi.org/10.3844/ajbbsp.2008.442.449" @default.
- W2103173075 hasPublicationYear "2008" @default.
- W2103173075 type Work @default.
- W2103173075 sameAs 2103173075 @default.
- W2103173075 citedByCount "0" @default.
- W2103173075 crossrefType "journal-article" @default.
- W2103173075 hasAuthorship W2103173075A5023185733 @default.
- W2103173075 hasAuthorship W2103173075A5024473758 @default.
- W2103173075 hasAuthorship W2103173075A5025825244 @default.
- W2103173075 hasAuthorship W2103173075A5031574077 @default.
- W2103173075 hasAuthorship W2103173075A5046617050 @default.
- W2103173075 hasConcept C134018914 @default.
- W2103173075 hasConcept C181199279 @default.
- W2103173075 hasConcept C185592680 @default.
- W2103173075 hasConcept C2777940757 @default.
- W2103173075 hasConcept C2781307694 @default.
- W2103173075 hasConcept C55493867 @default.
- W2103173075 hasConcept C86803240 @default.
- W2103173075 hasConceptScore W2103173075C134018914 @default.
- W2103173075 hasConceptScore W2103173075C181199279 @default.
- W2103173075 hasConceptScore W2103173075C185592680 @default.
- W2103173075 hasConceptScore W2103173075C2777940757 @default.
- W2103173075 hasConceptScore W2103173075C2781307694 @default.
- W2103173075 hasConceptScore W2103173075C55493867 @default.
- W2103173075 hasConceptScore W2103173075C86803240 @default.
- W2103173075 hasIssue "4" @default.
- W2103173075 hasLocation W21031730751 @default.
- W2103173075 hasOpenAccess W2103173075 @default.
- W2103173075 hasPrimaryLocation W21031730751 @default.
- W2103173075 hasRelatedWork W1986393148 @default.
- W2103173075 hasRelatedWork W1999329926 @default.
- W2103173075 hasRelatedWork W2004754196 @default.
- W2103173075 hasRelatedWork W2005719156 @default.
- W2103173075 hasRelatedWork W2021251732 @default.
- W2103173075 hasRelatedWork W2050485954 @default.
- W2103173075 hasRelatedWork W2081939424 @default.
- W2103173075 hasRelatedWork W2414415093 @default.
- W2103173075 hasRelatedWork W3010056926 @default.
- W2103173075 hasRelatedWork W76931571 @default.
- W2103173075 hasVolume "4" @default.
- W2103173075 isParatext "false" @default.
- W2103173075 isRetracted "false" @default.
- W2103173075 magId "2103173075" @default.
- W2103173075 workType "article" @default.