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- W2103173357 abstract "Transient neonatal hyperammonemia (TNH) was reviewed in six cases seen by the authors and in 27 selected from the literature. These 33 cases were compared with 13 infants with urea cycle enzyme deficiencies (UCED). The two groups were similar in sex distribution, routes of delivery, time of onset of seizures, Apgar scores and in the prevalence of perinatal complications. Patients with TNH had significantly lower birth weights (2,282±78 gm vs. 3,336±222; mean±SEM; P < 0.001) and gestational ages (35±0.5 vs. 40±0.5 weeks; p e 0.001). The mean time of onset of respiratory distress (4±1 vs. 72 2 26 hr; P < 0.001), need for ventilatory support (P < 0.001), time of onset of lethargy (P < 0.006) and coma (P < 0.005) all occurred earlier in patients with TNH than in those with UCED. Plasma ammonium concentra- tions were higher in patients with TNH than UCED (1,871±209 vs. 973±169 μM;P < 0.02). Respiratory distress occurred in all except one patient with TNH within the first 24 hr, while it occurred in none of the UCED patients within the first 30 hr and only one occurred in 62%of the latter group at any time. The clinical presentations of these two syndromes permit differentiation on clinical grounds alone." @default.
- W2103173357 created "2016-06-24" @default.
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- W2103173357 date "1986-11-01" @default.
- W2103173357 modified "2023-10-03" @default.
- W2103173357 title "Transient neonatal hyperammonemia: Squeezing an iceberg into a pigeon hole" @default.
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- W2103173357 doi "https://doi.org/10.1002/hep.1840060638" @default.
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