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• W2103175209 abstract "To explore the heterogeneity of CD4 responses following highly active antiretroviral therapy, the patterns of CD4 recovery of HIV-1-infected Chinese patients who have been on their first antiretroviral regimen for ≥5 years were analysed. The CD4 trajectories were traced, smoothed and differentiated into three defined profiles. Half (56.3%) were ‘satisfactory responders’, with CD4 gain of >100 cells/μL and a peak of >350 cells/μL, plateauing before the end of Year 5. Thirty-three (24.4%) were ‘continuing responders’ whose CD4 rise persisted at Year 4–5. The remaining 26 (19.3%) were ‘poor responders’. Presentation with AIDS before therapy was common not just among ‘poor’ but also paradoxically the ‘continuing’ responders. While a majority had responded well to antiretroviral therapy, older patients and those with AIDS diagnosis before initiation of therapy may never achieve a satisfactory level even with effective treatment. Categorization of HIV patients by their CD4 trajectory may support the prediction of immunological outcome over time, and ultimately inform treatment choices." @default.
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• W2103175209 date "2014-10-02" @default.
• W2103175209 modified "2023-10-14" @default.
• W2103175209 title "Three different patterns of CD4 recovery in a cohort of Chinese HIV patients following antiretroviral therapy – a five-year observational study" @default.
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• W2103175209 doi "https://doi.org/10.1177/0956462414553826" @default.
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