Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103175422> ?p ?o ?g. }
- W2103175422 endingPage "185" @default.
- W2103175422 startingPage "181" @default.
- W2103175422 abstract "Although the epidemiology of type 2 diabetes (T2D) has been well described, there is much about the disease that remains unclear. For example, lifestyle factors-including increased body weight with visceral fat deposition and insufficient physical activity-are thought to be primary contributors to the adverse changes in the metabolism of muscle and fat cells that comprise the first stage of the disease. However, the precise mechanisms underlying these initial alterations are incompletely understood. Other, less obvious questions relate to the presence of sex differences in the development and health consequences of T2D, the etiological role of the central nervous system (stress), and the potential evolutionary origins of T2D susceptibility. Some of these issues can be resolved by further study of human populations. However, many questions can be answered only through the kinds of controlled prospective studies that are conducted with appropriate animal models. The use of such models can be an invaluable part of an overall strategy designed to elucidate the mechanisms underlying the development of T2D, understand the natural history of the disease, identify targets for therapy, and evaluate interventions. Current evidence indicates that no single animal model replicates the development of human T2D in all of its details. Nonetheless, the existing models (e.g., naturally occurring and genetically modified rodents, cats, pigs, and nonhuman primates) offer researchers a rich array of opportunities to investigate the myriad complexities of T2D. The individual contributions comprising this issue of ILAR Journal review the research that has been conducted on many of these animals." @default.
- W2103175422 created "2016-06-24" @default.
- W2103175422 creator A5008053293 @default.
- W2103175422 creator A5049985984 @default.
- W2103175422 date "2006-01-01" @default.
- W2103175422 modified "2023-09-23" @default.
- W2103175422 title "Type 2 Diabetes--An Introduction to the Development and Use of Animal Models" @default.
- W2103175422 cites W1969111819 @default.
- W2103175422 cites W1982371528 @default.
- W2103175422 cites W1990955926 @default.
- W2103175422 cites W1992777999 @default.
- W2103175422 cites W2003538836 @default.
- W2103175422 cites W2003693236 @default.
- W2103175422 cites W2010994809 @default.
- W2103175422 cites W2036939737 @default.
- W2103175422 cites W2048565142 @default.
- W2103175422 cites W2048794583 @default.
- W2103175422 cites W2053158356 @default.
- W2103175422 cites W2059001716 @default.
- W2103175422 cites W2064176291 @default.
- W2103175422 cites W2069671127 @default.
- W2103175422 cites W2077609800 @default.
- W2103175422 cites W2083262340 @default.
- W2103175422 cites W2104706609 @default.
- W2103175422 cites W2117430622 @default.
- W2103175422 cites W2122538897 @default.
- W2103175422 cites W2126455207 @default.
- W2103175422 cites W2139785451 @default.
- W2103175422 cites W2144792258 @default.
- W2103175422 cites W2147154204 @default.
- W2103175422 cites W2155449017 @default.
- W2103175422 cites W2156884291 @default.
- W2103175422 cites W2157494695 @default.
- W2103175422 cites W2168162793 @default.
- W2103175422 cites W2170971994 @default.
- W2103175422 cites W2171716002 @default.
- W2103175422 doi "https://doi.org/10.1093/ilar.47.3.181" @default.
- W2103175422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16804193" @default.
- W2103175422 hasPublicationYear "2006" @default.
- W2103175422 type Work @default.
- W2103175422 sameAs 2103175422 @default.
- W2103175422 citedByCount "33" @default.
- W2103175422 countsByYear W21031754222012 @default.
- W2103175422 countsByYear W21031754222013 @default.
- W2103175422 countsByYear W21031754222014 @default.
- W2103175422 countsByYear W21031754222015 @default.
- W2103175422 countsByYear W21031754222016 @default.
- W2103175422 countsByYear W21031754222018 @default.
- W2103175422 countsByYear W21031754222020 @default.
- W2103175422 countsByYear W21031754222021 @default.
- W2103175422 countsByYear W21031754222022 @default.
- W2103175422 countsByYear W21031754222023 @default.
- W2103175422 crossrefType "journal-article" @default.
- W2103175422 hasAuthorship W2103175422A5008053293 @default.
- W2103175422 hasAuthorship W2103175422A5049985984 @default.
- W2103175422 hasBestOaLocation W21031754221 @default.
- W2103175422 hasConcept C118552586 @default.
- W2103175422 hasConcept C134018914 @default.
- W2103175422 hasConcept C142724271 @default.
- W2103175422 hasConcept C15744967 @default.
- W2103175422 hasConcept C169760540 @default.
- W2103175422 hasConcept C27415008 @default.
- W2103175422 hasConcept C2777180221 @default.
- W2103175422 hasConcept C2778117688 @default.
- W2103175422 hasConcept C2779134260 @default.
- W2103175422 hasConcept C555293320 @default.
- W2103175422 hasConcept C60644358 @default.
- W2103175422 hasConcept C71924100 @default.
- W2103175422 hasConcept C86803240 @default.
- W2103175422 hasConceptScore W2103175422C118552586 @default.
- W2103175422 hasConceptScore W2103175422C134018914 @default.
- W2103175422 hasConceptScore W2103175422C142724271 @default.
- W2103175422 hasConceptScore W2103175422C15744967 @default.
- W2103175422 hasConceptScore W2103175422C169760540 @default.
- W2103175422 hasConceptScore W2103175422C27415008 @default.
- W2103175422 hasConceptScore W2103175422C2777180221 @default.
- W2103175422 hasConceptScore W2103175422C2778117688 @default.
- W2103175422 hasConceptScore W2103175422C2779134260 @default.
- W2103175422 hasConceptScore W2103175422C555293320 @default.
- W2103175422 hasConceptScore W2103175422C60644358 @default.
- W2103175422 hasConceptScore W2103175422C71924100 @default.
- W2103175422 hasConceptScore W2103175422C86803240 @default.
- W2103175422 hasIssue "3" @default.
- W2103175422 hasLocation W21031754221 @default.
- W2103175422 hasLocation W21031754222 @default.
- W2103175422 hasLocation W21031754223 @default.
- W2103175422 hasOpenAccess W2103175422 @default.
- W2103175422 hasPrimaryLocation W21031754221 @default.
- W2103175422 hasRelatedWork W1563850031 @default.
- W2103175422 hasRelatedWork W1967563157 @default.
- W2103175422 hasRelatedWork W2091706513 @default.
- W2103175422 hasRelatedWork W2139521168 @default.
- W2103175422 hasRelatedWork W2389059307 @default.
- W2103175422 hasRelatedWork W2415759662 @default.
- W2103175422 hasRelatedWork W2748952813 @default.
- W2103175422 hasRelatedWork W2899084033 @default.
- W2103175422 hasRelatedWork W2973263109 @default.
- W2103175422 hasRelatedWork W4384342081 @default.