Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103177037> ?p ?o ?g. }
- W2103177037 endingPage "1697" @default.
- W2103177037 startingPage "1687" @default.
- W2103177037 abstract "Prostate cancer is the second most prevalent cancer in males in the United States. Standard therapy relies on removing, or blocking the actions of, androgens. In most cases, this therapy results in a regression of the cancer because the prostate and most primary prostate tumors depend on androgens for growth and the avoidance of apoptosis. However, a portion of the cancers eventually relapse, at which point they are termed androgen refractory and can no longer be cured by conventional therapy of any type. The precise molecular events that lead from androgen-sensitive prostate cancer to androgen-refractory prostate cancer are, therefore, of great interest. This review seeks to identify specific molecular events that may be linked directly to the progression to androgen-refractory cancer. Some of the mechanisms appear to involve the androgen receptor (AR) directly and include mutations in, or amplification of, the AR gene in a manner that allows the AR to respond to low doses of androgens, other steroids, or antiandrogens. In a less direct manner, coactivators may increase the sensitivity of the AR to androgens and even other nonandrogenic substances through a number of mechanisms. Additional indirect mechanisms that do not result from mutation of the AR may involve activation of the AR by peptide growth factors or cytokines or may involve bypassing the AR entirely via other cellular pathways. Identification of the role of these mechanisms in the progression to androgen-refractory prostate cancer is critical for developing therapies capable of curing this disease." @default.
- W2103177037 created "2016-06-24" @default.
- W2103177037 creator A5014512900 @default.
- W2103177037 creator A5016403795 @default.
- W2103177037 creator A5024723808 @default.
- W2103177037 date "2001-11-21" @default.
- W2103177037 modified "2023-10-12" @default.
- W2103177037 title "Androgen Receptor Signaling in Androgen-Refractory Prostate Cancer" @default.
- W2103177037 cites W1580523172 @default.
- W2103177037 cites W1644491781 @default.
- W2103177037 cites W187245126 @default.
- W2103177037 cites W1964279511 @default.
- W2103177037 cites W1965674043 @default.
- W2103177037 cites W1967819851 @default.
- W2103177037 cites W1970569586 @default.
- W2103177037 cites W1970629830 @default.
- W2103177037 cites W1976491226 @default.
- W2103177037 cites W1977416006 @default.
- W2103177037 cites W1980445173 @default.
- W2103177037 cites W1982552468 @default.
- W2103177037 cites W1984539870 @default.
- W2103177037 cites W1985827132 @default.
- W2103177037 cites W1988575537 @default.
- W2103177037 cites W1988679331 @default.
- W2103177037 cites W1994355495 @default.
- W2103177037 cites W1994477430 @default.
- W2103177037 cites W1995300917 @default.
- W2103177037 cites W1995328990 @default.
- W2103177037 cites W1996835624 @default.
- W2103177037 cites W2000906131 @default.
- W2103177037 cites W2005873549 @default.
- W2103177037 cites W2008498145 @default.
- W2103177037 cites W2009269691 @default.
- W2103177037 cites W2010013468 @default.
- W2103177037 cites W2012865220 @default.
- W2103177037 cites W2013981968 @default.
- W2103177037 cites W2014145760 @default.
- W2103177037 cites W2014987459 @default.
- W2103177037 cites W2016529301 @default.
- W2103177037 cites W2019042050 @default.
- W2103177037 cites W2020636054 @default.
- W2103177037 cites W2020772481 @default.
- W2103177037 cites W2020891498 @default.
- W2103177037 cites W2022635468 @default.
- W2103177037 cites W2031465452 @default.
- W2103177037 cites W2034269086 @default.
- W2103177037 cites W2041719533 @default.
- W2103177037 cites W2043236550 @default.
- W2103177037 cites W2044155146 @default.
- W2103177037 cites W2046067408 @default.
- W2103177037 cites W2054045654 @default.
- W2103177037 cites W2058733098 @default.
- W2103177037 cites W2059906457 @default.
- W2103177037 cites W2060739426 @default.
- W2103177037 cites W2061783153 @default.
- W2103177037 cites W2064426272 @default.
- W2103177037 cites W2064509352 @default.
- W2103177037 cites W2068345721 @default.
- W2103177037 cites W2071914496 @default.
- W2103177037 cites W2072891243 @default.
- W2103177037 cites W2073069369 @default.
- W2103177037 cites W2077041282 @default.
- W2103177037 cites W2085609235 @default.
- W2103177037 cites W2087015197 @default.
- W2103177037 cites W2087329787 @default.
- W2103177037 cites W2111125738 @default.
- W2103177037 cites W2111752734 @default.
- W2103177037 cites W2120040531 @default.
- W2103177037 cites W2122522737 @default.
- W2103177037 cites W2123927174 @default.
- W2103177037 cites W2124174146 @default.
- W2103177037 cites W2124897613 @default.
- W2103177037 cites W2129750923 @default.
- W2103177037 cites W2130404651 @default.
- W2103177037 cites W2132728194 @default.
- W2103177037 cites W2137577449 @default.
- W2103177037 cites W2146157811 @default.
- W2103177037 cites W2147114673 @default.
- W2103177037 cites W2150127705 @default.
- W2103177037 cites W2151453176 @default.
- W2103177037 cites W2152988906 @default.
- W2103177037 cites W2153030011 @default.
- W2103177037 cites W2156449667 @default.
- W2103177037 cites W2161810908 @default.
- W2103177037 cites W2167768067 @default.
- W2103177037 cites W2170677834 @default.
- W2103177037 cites W2340799873 @default.
- W2103177037 cites W2399925819 @default.
- W2103177037 cites W2407462782 @default.
- W2103177037 cites W2426196179 @default.
- W2103177037 cites W2617245288 @default.
- W2103177037 cites W4230009137 @default.
- W2103177037 cites W4239400520 @default.
- W2103177037 cites W4242032496 @default.
- W2103177037 cites W4247336065 @default.
- W2103177037 cites W4249832147 @default.
- W2103177037 cites W4298355764 @default.
- W2103177037 cites W51158438 @default.