Matches in SemOpenAlex for { <https://semopenalex.org/work/W2103181017> ?p ?o ?g. }
- W2103181017 endingPage "E1264" @default.
- W2103181017 startingPage "E1256" @default.
- W2103181017 abstract "We measured the impact of chronic late gestation hypoglycemia on pancreatic islet structure and function to determine the cause of decreased insulin secretion in this sheep model of fetal nutrient deprivation. Late gestation hypoglycemia did not decrease pancreas weight, insulin content, beta-cell area, beta-cell mass, or islet size. The pancreatic islet isolation procedure selected a group of islets that were larger and had an increased proportion of beta-cells compared with islets measured in pancreatic sections, but there were no morphologic differences between islets isolated from control and hypoglycemic fetuses. The rates of glucose-stimulated pancreatic islet glucose utilization (126.2 +/- 25.3 pmol glucose.islet(-1).h(-1), hypoglycemic, vs. 93.5 +/- 5.5 pmol glucose.islet(-1).h(-1), control, P = 0.47) and oxidation (10.5 +/- 1.7 pmol glucose.islet(-1).h(-1), hypoglycemic, vs. 10.6 +/- 1.6 pmol glucose.islet(-1).h(-1), control) were not different in hypoglycemic fetuses compared with control fetuses. Chronic late gestation hypoglycemia decreased insulin secretion in isolated pancreatic islets by almost 70% in response to direct nonnutrient membrane depolarization and in response to increased extracellular calcium entry. beta-Cell ultrastructure was abnormal with markedly distended rough endoplasmic reticulum in three of the seven hypoglycemic fetuses studied, but in vitro analysis of hypoglycemic control islets showed no evidence that these changes represented endoplasmic reticulum stress, as measured by transcription of glucose regulatory protein-78 and processing of X-box binding protein-1. In conclusion, these studies show that chronic hypoglycemia in late gestation decreases insulin secretion by inhibiting the later steps of stimulus-secretion coupling after glucose metabolism, membrane depolarization, and calcium entry." @default.
- W2103181017 created "2016-06-24" @default.
- W2103181017 creator A5007966429 @default.
- W2103181017 creator A5049773569 @default.
- W2103181017 creator A5072337628 @default.
- W2103181017 creator A5081318932 @default.
- W2103181017 date "2007-05-01" @default.
- W2103181017 modified "2023-10-02" @default.
- W2103181017 title "Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic β-cells" @default.
- W2103181017 cites W1911524033 @default.
- W2103181017 cites W1980922396 @default.
- W2103181017 cites W1986836799 @default.
- W2103181017 cites W2004145345 @default.
- W2103181017 cites W2013094139 @default.
- W2103181017 cites W2015838103 @default.
- W2103181017 cites W2019073316 @default.
- W2103181017 cites W2021206670 @default.
- W2103181017 cites W2022185109 @default.
- W2103181017 cites W2024475665 @default.
- W2103181017 cites W2031792984 @default.
- W2103181017 cites W2073500040 @default.
- W2103181017 cites W2105434442 @default.
- W2103181017 cites W2107601804 @default.
- W2103181017 cites W2112253737 @default.
- W2103181017 cites W2116597622 @default.
- W2103181017 cites W2116947215 @default.
- W2103181017 cites W2119902047 @default.
- W2103181017 cites W2122258473 @default.
- W2103181017 cites W2128167237 @default.
- W2103181017 cites W2131875219 @default.
- W2103181017 cites W2141328025 @default.
- W2103181017 cites W2143571999 @default.
- W2103181017 cites W2158068037 @default.
- W2103181017 cites W2164467454 @default.
- W2103181017 cites W2247538616 @default.
- W2103181017 cites W2424410387 @default.
- W2103181017 cites W4231115141 @default.
- W2103181017 cites W4256495376 @default.
- W2103181017 doi "https://doi.org/10.1152/ajpendo.00265.2006" @default.
- W2103181017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17213478" @default.
- W2103181017 hasPublicationYear "2007" @default.
- W2103181017 type Work @default.
- W2103181017 sameAs 2103181017 @default.
- W2103181017 citedByCount "30" @default.
- W2103181017 countsByYear W21031810172012 @default.
- W2103181017 countsByYear W21031810172013 @default.
- W2103181017 countsByYear W21031810172014 @default.
- W2103181017 countsByYear W21031810172015 @default.
- W2103181017 countsByYear W21031810172016 @default.
- W2103181017 countsByYear W21031810172017 @default.
- W2103181017 countsByYear W21031810172018 @default.
- W2103181017 countsByYear W21031810172020 @default.
- W2103181017 countsByYear W21031810172023 @default.
- W2103181017 crossrefType "journal-article" @default.
- W2103181017 hasAuthorship W2103181017A5007966429 @default.
- W2103181017 hasAuthorship W2103181017A5049773569 @default.
- W2103181017 hasAuthorship W2103181017A5072337628 @default.
- W2103181017 hasAuthorship W2103181017A5081318932 @default.
- W2103181017 hasConcept C126322002 @default.
- W2103181017 hasConcept C134018914 @default.
- W2103181017 hasConcept C144855686 @default.
- W2103181017 hasConcept C158617107 @default.
- W2103181017 hasConcept C165220095 @default.
- W2103181017 hasConcept C172680121 @default.
- W2103181017 hasConcept C2776054734 @default.
- W2103181017 hasConcept C2776828364 @default.
- W2103181017 hasConcept C2777391703 @default.
- W2103181017 hasConcept C2778764654 @default.
- W2103181017 hasConcept C2779234561 @default.
- W2103181017 hasConcept C2779306644 @default.
- W2103181017 hasConcept C2779855799 @default.
- W2103181017 hasConcept C2780352109 @default.
- W2103181017 hasConcept C2780668416 @default.
- W2103181017 hasConcept C46973012 @default.
- W2103181017 hasConcept C54355233 @default.
- W2103181017 hasConcept C55493867 @default.
- W2103181017 hasConcept C71924100 @default.
- W2103181017 hasConcept C86803240 @default.
- W2103181017 hasConceptScore W2103181017C126322002 @default.
- W2103181017 hasConceptScore W2103181017C134018914 @default.
- W2103181017 hasConceptScore W2103181017C144855686 @default.
- W2103181017 hasConceptScore W2103181017C158617107 @default.
- W2103181017 hasConceptScore W2103181017C165220095 @default.
- W2103181017 hasConceptScore W2103181017C172680121 @default.
- W2103181017 hasConceptScore W2103181017C2776054734 @default.
- W2103181017 hasConceptScore W2103181017C2776828364 @default.
- W2103181017 hasConceptScore W2103181017C2777391703 @default.
- W2103181017 hasConceptScore W2103181017C2778764654 @default.
- W2103181017 hasConceptScore W2103181017C2779234561 @default.
- W2103181017 hasConceptScore W2103181017C2779306644 @default.
- W2103181017 hasConceptScore W2103181017C2779855799 @default.
- W2103181017 hasConceptScore W2103181017C2780352109 @default.
- W2103181017 hasConceptScore W2103181017C2780668416 @default.
- W2103181017 hasConceptScore W2103181017C46973012 @default.
- W2103181017 hasConceptScore W2103181017C54355233 @default.
- W2103181017 hasConceptScore W2103181017C55493867 @default.
- W2103181017 hasConceptScore W2103181017C71924100 @default.
- W2103181017 hasConceptScore W2103181017C86803240 @default.