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• W2103181208 abstract "The maize MuDR/Mu transposable elements are highly aggressive, and their activities are held in check by host developmental and epigenetic mechanisms. The Mutator regulatory element, MuDR, produces both sense and antisense transcripts. We have investigated the impact of the presence of antisense transcripts on the abundance of the corresponding sense messages and on the regulation of Mutator activities. We report that internal deletions in MuDR arise frequently in somatic tissues; preferential loss of the 3' untranslated region of mudrA and/or mudrB containing the intergenic region is correlated with chimeric sense mudrA/antisense mudrB and sense mudrB/antisense mudrA transcripts. Heritable internal deletions are extremely frequent (>10(-2) per element), and the resulting defective MuDR elements also encode antisense transcripts. Expression of endogenous or additional transgene-encoded antisense transcripts neither decreases sense transcript levels nor inhibits Mutator excision activity over the three generations examined. We propose that antisense transcripts produced by MuDR deletions are not dominant-negative regulators of Mutator activities." @default.
• W2103181208 created "2016-06-24" @default.
• W2103181208 creator A5026797913 @default.
• W2103181208 creator A5039165747 @default.
• W2103181208 date "2003-10-01" @default.
• W2103181208 modified "2023-10-16" @default.
• W2103181208 title "Deletion Derivatives of the MuDR Regulatory Transposon of Maize Encode Antisense Transcripts but Are Not Dominant-Negative Regulators of Mutator Activities" @default.
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• W2103181208 doi "https://doi.org/10.1105/tpc.014605" @default.
• W2103181208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/197307" @default.
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• W2103181208 hasPublicationYear "2003" @default.
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