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- W2103181632 endingPage "5897" @default.
- W2103181632 startingPage "5891" @default.
- W2103181632 abstract "Kinetoplast DNA, the mitochondrial DNA of trypanosomes, is a topologically complex structure composed of interlocked minicircles and maxicircles. We previously reported that etoposide, a potent inhibitor of topoisomerase II, promotes the cleavage of about 20% of network minicircle DNA (T. A. Shapiro, V. A. Klein, and P. T. Englund, J. Biol. Chem. 264:4173-4178, 1989). We now find that virtually all maxicircles are released from kinetoplast DNA networks after trypanosomes are treated with etoposide. As expected for a topoisomerase II cleavage product, the linearized maxicircles have protein bound to both 5' ends. After etoposide treatment, the residual minicircle catenanes have a sedimentation coefficient which is only 70% that of controls, and by electron microscopy the networks are less compact. Double-size networks, the characteristic dumbbell-shape forms that normally arise in the final stages of network replication, are replaced by aberrant unit-size forms." @default.
- W2103181632 created "2016-06-24" @default.
- W2103181632 creator A5077230926 @default.
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- W2103181632 date "1994-09-01" @default.
- W2103181632 modified "2023-10-18" @default.
- W2103181632 title "In vivo inhibition of trypanosome mitochondrial topoisomerase II: effects on kinetoplast DNA maxicircles." @default.
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- W2103181632 doi "https://doi.org/10.1128/mcb.14.9.5891" @default.
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